6 documents found, page 1 of 1
Anesthesia for muscle biopsy to test susceptibility to malignant hyperthermia
Silva,Helga Cristina Almeida da; Onari,Elton Shinji; Castro,Isac de; Perez,Marcelo Vaz; Hortensi,Alexandre; Amaral,José Luiz Gomes doAbstract Introduction Malignant hyperthermia is an autosomal dominant pharmacogenetic disorder, characterized by hypermetabolic crisis triggered by halogenated anesthetics and/or succinylcholine. The standard method for diagnosing malignant hyperthermia susceptibility is the in vitro muscle contracture test in response to halothane-caffeine, which requires muscle biopsy under anesthesia. We describe a series of...
Late onset multiple sclerosis: concerns in aging patients
Lotti,Claudia Beatriz de Campos; Oliveira,Acary Souza Bulle; Bichuetti,Denis Bernardi; Castro,Isac de; Oliveira,Enedina Maria LobatoABSTRACT Late onset multiple sclerosis (LOMS) is when the first symptom starts after 50 years of age, representing 4.5% of multiple sclerosis (MS) patients. This study describes the clinical characteristics of patients with LOMS followed at a specialized MS center in São Paulo. Data was obtained from medical records of 742 patients with MS. The LOMS frequency was 4.18%, median age at onset was 54 years and the ...
Epidemiological and clinical factors impact on the benefit of riluzole in the s...
Fávero,Francis Meire; Voos,Mariana Callil; Castro,Isac de; Caromano,Fátima Aparecida; Oliveira,Acary Souza BulleABSTRACT Objective To investigate the impact of epidemiological and clinical factors on the benefit of riluzole in patients with amyotrophic lateral sclerosis (ALS). Methods The survival rate of 578 patients with ALS (1999-2011) was analyzed by descriptive statistics and Kaplan-Meier curves. Considering the median of the sample survival time (19 months), patients were divided in two groups: below (B19) and abov...
Risk factors for the progression of chronic kidney disease after acute kidney i...
Pereira,Benedito Jorge; Barreto,Silvana; Gentil,Thais; Assis,Larissa S.; Soeiro,Emília MD; Castro,Isac de; Laranja,Sandra M.Abstract Introduction: The incidence of chronic kidney disease (CKD) is increasing with the increasing age of the population and the increasing number of elderly survivors of acute kidney injury (AKI). The risk factors for the progression of CKD after AKI are unclear. Objective: To investigate the association between AKI and its progression to CKD and the risk factors involved. Methods: An observational, retros...
Diabetes subdiagnosticado e necrose miocárdica: preditores de hiperglicemia no ...
Ladeira,Renata Teixeira; Baracioli,Luciano Moreira; Faulin,Tanize Espírito Santo; Abdalla,Dulcinéia Saes Parra; Seydell,Talita MatttosFUNDAMENTO: Hiperglicemia na fase aguda do infarto do miocárdio é importante fator prognóstico. Entretanto, sua fisiopatologia não está completamente elucidada. OBJETIVO: Analisar simultaneamente correlação entre hiperglicemia e marcadores bioquímicos relacionados ao estresse,metabolismo glicídico e lipídico, coagulação, inflamação e necrose miocárdica. MÉTODOS: Oitenta pacientes com infarto agudo do miocárdio ...
Correlation between serum tumor necrosis factor alpha levels and clinical sever...
Andrade Júnior,Dahir Ramos de; Santos,Sânia Alves dos; Castro,Isac de; Andrade,Dahir Ramos deThis study verified the correlation between the serum levels of TNF alpha and different clinical forms of tuberculosis. We described a group of 24 patients presenting several clinical forms of tuberculosis and a control group of 13 healthy individuals. The levels of TNF alpha were measured by bioassay method. The levels of TNF-alpha had significant differences between the tuberculosis and control groups. The pa...