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Assessing response to stressful emotions: a controlled crossover study using pu...

Noronha, AC; Castro Mendes, F; Carvalho, P; Fonseca, M; Paciência, I; Moreira, A

"Background: Fear and horror induce autonomic protective responses, acting as ""survival intelligence."" Pupillometry is an innovative method that captures real-time autonomic nervous system reactions to stress. Objective: To evaluate the feasibility of pupillometry to assess the acute response to a passive real-life stressor-viewing a truthful war scene. Methods: Thirteen medical students (10 women) with an av...


Does the Mediterranean Dietary Pattern Promote Lower Sodium Urinary Excretion i...

Rodrigues, M; Castro Mendes, F; Padrão, P; Delgado, L; Barros, R; Cavaleiro Rufo, J; Silva, D; Moreira, A; Moreira, P

An adequate sodium intake is related to various health benefits. Parallelly, the Mediterranean diet (MD) is a dietary pattern known for its many positive impacts on health. Nonetheless, the association between adherence to the MD and sodium urinary excretion is scarce, even more in children. This study aimed to assess the association between MD adherence and the excretion of sodium, as a proxy of intake. This c...


Allergen immunotherapy for asthma prevention: A systematic review and meta-anal...

Farraia, M; Paciência, I; Castro Mendes, F; Cavaleiro Rufo, J; Shamji, M; Agache, I; Moreira, A

Background: Allergen immunotherapy (AIT) is a disease-modifying treatment for IgE-mediated diseases. Randomized controlled trials (RCTs) support AIT's potential role in asthma prevention but evidence from non-randomized studies of interventions (NRSI) and longitudinal observational studies has been poorly addressed. Therefore, we aimed to conduct a systematic review and meta-analysis to assess clinical data fro...


Cost-effectiveness analysis of house dust mite allergen immunotherapy in childr...

Farraia, M; Paciência, I; Castro Mendes, F; Cavaleiro Rufo, J; Shamji, MH; Agache, I; Moreira, A

Background: Cost-effectiveness studies evaluating allergen immunotherapy (AIT) in children are limited but needed to drive clinical and policy-making decisions such as reimbursement of new interventions. In this study, we compared the cost effectiveness of subcutaneous (SCIT) and sublingual immunotherapy (SLIT) tablets to the standard of care (SOC) treatment in children with house dust mite-driven (HDM) allergi...


Airborne Food Allergen and Aeroallergen Levels in Health Care Settings: An Unac...

Leal, M; Paciência, I; Farraia, M; Cavaleiro Rufo, J; Castro Mendes, F; Delgado, L; Viegas, C; Moreira, A

Background and objective: Exposure to airborne allergens of biological origin is associated with the development and exacerbation of allergic asthma and rhinitis. Assessment of allergen exposure in health care facilities may improve monitoring of hygiene and surveillance of specific allergens that can cause symptoms in sensitized persons. Objective: To assess concentrations of airborne food and aeroallergens in...


Environmental quality in primary schools and related health effects in children...

Fonseca Gabriel, M; Paciência, I; Felgueiras, F; Cavaleiro Rufo, J; Castro Mendes, F; Farraia, M; Mourão, Z; Moreira, A; de Oliveira Fernandes, E


The inflammatory potential of diet impacts the association between air pollutio...

Castro Mendes, F; Paciência, I; Cavaleiro Rufo, J; Silva, D; Cunha, P; Farraia, M; Delgado, L; GarciaLarsen, V; Severo, M; Moreira, A; Moreira, Pedro


Dietary Acid Load: A Novel Nutritional Target in Overweight/Obese Children with...

Cunha, P.; Paciência, I; Cavaleiro Rufo, J; Castro Mendes, F; Farraia, M; Barros, Renata; Silva, D; Delgado, L; Padrão, Patrícia; Moreira, André

<jats:p>Obesity has been repeatedly linked to asthma, and several potential mechanisms have been proposed in the etiologies of the obese-asthma phenotype. Considering that lungs play an important role in systemic pH and acidbase regulation, are a key organ in asthma development, and that nutritional inadequacy of several nutrients and high dietary acid load can affect airway inflammation and reactivity, we aime...


Metabolic interactions in asthma

Farraia, M; Cavaleiro Rufo, J; Paciência, I; Castro Mendes, F; Delgado, L; Laerte Boechat, J; Moreira, A

Metabolomics can be used to explore altered metabolic pathways in asthma, giving insights into its pathophysiology. We aimed to review how metabolomics has been used to understand asthma by describing metabolic pathways under research and discussing clinical implications. The search was performed in PubMed, and studies published since 2000 using a metabolomics approach, were included. A total of 32 studies were...


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