5 documents found, page 1 of 1
Lipid Antigen Presentation by CD1b and CD1d in Lysosomal Storage Disease Patients
Pereira, C.; Pérez-Cabezas, B.; Ribeiro, H.; Maia, M.; Cardoso, M.; Dias, A.; Azevedo, O.; Ferreira, M.; Garcia, P.; Rodrigues, E.; Castro-Chaves, P.The lysosome has a key role in the presentation of lipid antigens by CD1 molecules. While defects in lipid antigen presentation and in invariant Natural Killer T (iNKT) cell response were detected in several mouse models of lysosomal storage diseases (LSD), the impact of lysosomal engorgement in human lipid antigen presentation is poorly characterized. Here, we analyzed the capacity of monocyte-derived dendriti...
Neuregulin-1 improves right ventricular function and attenuates experimental pu...
Mendes-Ferreira, P.; Maia-Rocha, C.; Adão, R.; Mendes, M.J.; Santos-Ribeiro, D.; Silvana Alves, B.; Cerqueira, R.J.; Castro-Chaves, P.; Lourenço, A.P.Aims Pulmonary arterial hypertension (PAH) is a serious disease that affects both the pulmonary vasculature and the right ventricle (RV). Current treatment options are insufficient. The cardiac neuregulin (NRG)-1/ErbB system is deregulatedduring heart failure, and treatment with recombinant human NRG-1 (rhNRG-1) has been shown to be beneficial inanimal models and in patients with left ventricular (LV) dysfuncti...
A neuregulina-1 atenua a disfunção endotelial na hipertensão arterial pulmonar
Mendes-Ferreira, P.; Adão, R.; Cerqueira, R.J.; Maia-Rocha, C.; Mendes, M.J.; Castro-Chaves, P.; De Keulenaer, G.W.; Leite-Moreira, A.F.[abstract]
Neuregulin attenuates pulmonary endothelial dysfunction in pulmonary hypertension
Mendes-Ferreira, P.; Adão, R.; Maia-Rocha, C.; Cerqueira, R.J.; Mendes, M.J.; Castro-Chaves, P.; De Keulenaer, G.W.; Leite-Moreira, A.F.[abstract]
Neuregulin attenuates right ventricular hypertrophy and dysfunction in an exper...
Mendes-Ferreira, P.; Maia-Rocha, C.; Adão, R.; Lourenço, A.P.; Cerqueira, R.; Mendes, M.J.; Castro-Chaves, P.; De Keulenaer, G.W.; Leite-Moreira, A.F.[abstract]