5 documents found, page 1 of 1
Ketamine combined with psychotherapy for treatment-resistant depression
Cohen, Rebeca; Bastos, João; Cunha, Catarina; Marguilho, Miriam; Sancho, Ana; Silva, Maria João Matos; King, Franklin; Castro-Rodrigues, PedroKetamine, an N -methyl- d -aspartate antagonist, shows promise for treatment-resistant depression (TRD), with psychedelic doses potentially enhancing efficacy. However, its transient antidepressant effects and the need for repeated infusions raise concerns about optimal duration and long-term safety. Two clinical trials have tested the combination of ketamine with psychotherapy for depression, with mixed result...
Deprescribing Antidepressants: A Gap in Psychiatry Training and Research
Cohen, Rebeca; Castro-Rodrigues, Pedron/a.; n/d.
Cross-cultural Adaptation and Psychometric Validation of a Structured Interview...
Almeida, Sílvia; Castro-Rodrigues, Pedro; Barahona-Corrêa, J Bernardo; Baptista, Telmo Mourinho; Grácio, Jaime; Oliveira-Maia, Albino JPsychiatric disorders are a significant cause of long-term disability and mortality. Although treatment is available, diagnostic accuracy is critical to provide adequate evidence-based treatment and to develop novel therapies. To inform the diagnostic process during clinical interviews, the use of validated assessment measures, including self-report questionnaires and structured interviews, is highly recommende...
Explicit knowledge of task structure is a primary determinant of human model-ba...
Castro-Rodrigues, Pedro; Akam, Thomas; Snorasson, Ivar; Camacho, Marta; Paixão, Vitor; Maia, Ana; Barahona-Corrêa, J. Bernardo; Dayan, PeterExplicit information obtained through instruction profoundly shapes human choice behaviour. However, this has been studied in computationally simple tasks, and it is unknown how model-based and model-free systems, respectively generating goal-directed and habitual actions, are affected by the absence or presence of instructions. We assessed behaviour in a variant of a computationally more complex decision-makin...
Mecanismos Cerebrais de Aprendizagem pelo Reforço na Perturbação Obsessivo-Comp...
Castro-Rodrigues, Pedro; Barahona-Corrêa, Bernardo; Oliveira-Maia, AlbinoIntrodução: A Perturbação Obsessivo-Compulsiva (POC) é uma perturbação neuropsiquiátrica crónica cujo tratamento, farmacológico ou psicoterapêutico, é ineficaz numa percentagem significativa de casos, exigindo uma melhor compreensão da perturbação. Estudos realizados nestes doentes sugerem a existência de disfunção nos sistemas cerebrais responsáveis pela aprendizagem de novas acções, nomeadamente em circuitos ...