4 documents found, page 1 of 1
Tissular growth factors profile after teduglutide administration on an animal m...
Costa, Beatriz P.; Gonçalves, Ana C.; Abrantes, Ana M.; Alves, Raquel; Matafome, Paulo N.; Seiça, Raquel; Ribeiro, Ana B. Sarmento; Botelho, M. FilomenaBackground: Teduglutide is an enterotrophic analogue of glucagon-like peptide-2, with an indirect and poorly understood mechanism of action, approved for the rehabilitation of short-bowel syndrome. This study aims to analyze the response of tissue growth factors to surgical injury and teduglutide administration on an animal model of intestinal anastomosis. Methods: Wistar rats (n = 59) were distributed into fou...
Intestinal inflammatory and redox responses to the perioperative administration...
Costa, Beatriz Pinto; Gonçalves, Ana Cristina; Abrantes, Ana M.; Matafome, Paulo N.; Seiça, Raquel; Ribeiro, Ana Bela Sarmento; Botelho, Maria FilomenaPurpose: To investigate the inflammatory and redox responses to teduglutide on an animal model of laparotomy and intestinal anastomosis. Methods: Wistar rats (n=62) were allocated into four groups: “Ileal Resection and Anastomosis” vs. “Laparotomy”, each one split into “Postoperative Teduglutide Administration” vs. “No Treatment”; and euthanized at the third or the seventh day. Ileal and blood samples were reco...
Hepatic Angiosarcoma Masquerading as Hemangioma: A Challenging Differential Dia...
Garcia, Ana Rita; Ribeiro, João; Gervásio, Helena; Castro-Sousa, FranciscoHemangiomas are usually diagnosed based on ultrasound findings. The presence of symptoms, rapid growth or atipical imagiological findings should make us consider other diagnoses, including malignant tumors such as angiosarcomas. We describe the case of a previously healthy 46-year-old female without a history of exposure to carcinogens who presented with abdominal pain for two months. Diagnostic work-up reveale...
Prevalence and characteristics of Epstein-Barr virus-associated gastric carcino...
Nogueira, Célia; Mota, Marta; Gradiz, Rui; Cipriano, Maria Augusta; Caramelo, Francisco; Cruz, Hugo; Alarcão, Ana; Castro-Sousa, FranciscoBackground: Gastric cancer (GC) is one of the most common malignant tumors of the digestive tract and is the third leading cause of cancer death worldwide. Epstein–Barr virus (EBV) has been associated with approximately 10% of the total cases of gastric carcinomas. No previous study has analyzed the prevalence of EBV infection in gastric cancer of the Portuguese population. Methods: In the present study, we hav...