Submitted by Simone Maisonave (simonemaisonave@hotmail.com) on 2022-09-01T12:45:20Z No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Dissertacao_Leticia_Ribeiro.pdf: 1061726 bytes, checksum: ecbd294909e6401af53d30b4b27fefdd (MD5); Approved for entry into archive by Aline Batista (alinehb.ufpel@gmail.com) on 2022-09-06T23:45:17Z (GMT) No. of bitstreams: 2 Dissertacao_Le...
Submitted by Boris Flegr (boris@uerj.br) on 2020-07-05T16:10:00Z No. of bitstreams: 2 Dissertacao Leticia Ribeiro restrito.pdf: 586135 bytes, checksum: 362e3fd0cd38e384423713dda9199b42 (MD5) Dissertacao Leticia Ribeiro completo bloqueado.pdf: 744403 bytes, checksum: 1e51b3c47496831312e8e19824774de1 (MD5); Made available in DSpace on 2020-07-05T16:10:00Z (GMT). No. of bitstreams: 2 Dissertacao Leticia Ribeiro re...
ABL1 tyrosine kinase inhibitors (TKI) have dramatically improved the outcome for chronic myeloid leukaemia (CML) patients, resulting in a life expectancy that approaches that of the general population. Nevertheless, lifelong TKI therapy may have consequences, including chronic adverse events that can substantially impact patients’ quality of life, adherence to therapy and treatment success. Recently, several cl...
This article analyzes the tension between equality and difference in contemporary Brazilian feminism and the implications of this discussion to the challenges of implementing and expanding democracy. The main methodological resource was participant observation of the events and reunions of the Rio de Janeiro Slutwalk activists between may and august 2014. In the years following, other feminists initiatives at R...
Introdução: A síndrome mielodisplásica é uma doença heterogénea caracterizada por displasia, medula hipercelular, citopenias e risco de evolução para leucemia aguda. Outros factores de prognóstico, nomeadamente, fibrose medular, elevação da enzima desidrogenase do lactato e β2-microglobulina têm sido descritos, contudo, a decisão terapêutica baseia-se no score do International Prognostic Scoring System. Materia...
Introduction: This myelodysplastic syndromes are a heterogeneous entity characterized by dysplasia, hypercellular bone marrow, cytopenias and risk of transformation to acute leukaemia. Prognostic factors, such as bone marrow fibrosis, lactate dehydrogenase and β2-microglobulin elevation have been described, but treatment is mainly based in the International Prognostic Scoring System.Material and Methods: Our ai...
Background: Pyruvate kinase (PK) deficiency, causing hemolytic anemia, has been associated to malaria protection and its prevalence in sub-Saharan Africa is not known so far. This work shows the results of a study undertaken to determine PK deficiency occurrence in some sub-Saharan African countries, as well as finding a prevalent PK variant underlying this deficiency. Materials and Methods: Blood samples of in...
Malaria has occurred in the Cabo Verde archipelago with epidemic characteristics since its colonization. Nowadays, it occurs in Santiago Island alone and though prophylaxis is not recommended by the World Health Organization, studies have highlight the prospect of malaria becoming a serious public health problem as a result of the presence of antimalarial drug resistance associated with mutations in the parasit...