5 documents found, page 1 of 1
Pharmacogenetics of advanced lung cancer: Predictive value of functional geneti...
Catarata, MJ; Lourenço, M; Martins, MF; Frade, J; Pêgo, A; Cordeiro, CR; Medeiros, R; Ribeiro, RIntroduction: AGXT gene codes for the enzyme alanine glyoxylate aminotransferase, which is involved in hepatic peroxisomal metabolism of platinum-based chemotherapeutic agents. The association of genetic variant AGXT rs34116584 on the clinical outcome and response to chemotherapy of patients with non-small cell lung cancer (NSCLC) remains to be established. Our aim was to evaluate the association of functional ...
Asthma App Use and Interest Among Patients With Asthma: A Multicenter Study
Jácome, C; Almeida, R; Pereira, AM; Araújo, L; Correia, MA; Pereira, M; Couto, M; Lopes, C; Chaves Loureiro, C; Catarata, MJ; Santos, LM; Ramos, B
Germline genetic variants of the renin-angiotensin system, hypoxia and angiogen...
Catarata, MJ; Medeiros, R; Oliveira, MJ; Pêgo, A; Frade, JG; Martins, MF; Cordeiro, CR; Herth, FJF; Thomas, M; Kriegsmann, M; Meister, M; Schneider, MAIntroduction: The renin–angiotensin system (RAS) is involved in cell proliferation, immunoinflammatory response, hypoxia and angiogenesis, which are critical biological processes in lung cancer. Our aim was to study the association of putatively functional genetic polymorphisms in genes coding for proteins involved in RAS, hypoxia and angiogenesis with non-small cell lung cancer (NSCLC) prognosis. Methods: Geno...
Renin-angiotensin system in lung tumor and microenvironment interactions
Catarata, MJ; Ribeiro, R; Oliveira, MJ; Cordeiro, CR; Medeiros, RThe mechanistic involvement of the renin-angiotensin system (RAS) reaches beyond cardiovascular physiopathology. Recent knowledge pinpoints a pleiotropic role for this system, particularly in the lung, and mainly through locally regulated alternative molecules and secondary pathways. Angiotensin peptides play a role in cell proliferation, immunoinflammatory response, hypoxia and angiogenesis, which are critical...
Patient-Physician Discordance in Assessment of Adherence to Inhaled Controller ...
Jácome, C; Pereira, AM; Almeida, R; Ferreira-Magalhaes, M; Couto, M; Araujo, L; Pereira, M; Alves Correia, M; Chaves Loureiro, C; Catarata, MJOBJECTIVE: We aimed to compare patient's and physician's ratings of inhaled medication adherence and to identify predictors of patient-physician discordance. DESIGN: Baseline data from two prospective multicentre observational studies. SETTING: 29 allergy, pulmonology and paediatric secondary care outpatient clinics in Portugal. PARTICIPANTS: 395 patients (≥13 years old) with persistent asthma. MEASURES: Data o...