6 documents found, page 1 of 1

Unveiling the traits of HER2-low breast cancer: a comparative analysis of IHC1+...

Background: Half of all breast cancer (BC) cases fall into the HER2-low category, defined as immunohistochemistry (IHC) 1+ or IHC 2+ in situ hybridization negative (ISH-). Two-thirds of these cases are IHC1+, while one-third is IHC2+/ISH-. New anti-HER2 antibody-drug conjugates (ADCs) have emerged as treatment options for metastatic or unresectable HER2-low BC patients. However, the heterogeneity between IHC1+ ...

Prognosis of polymerase epsilon (POLE) mutation in high-grade endometrioid endo...

Background. POLE mutated endometrial carcinomas may represent a subspecific type of tumors harboring a more favorable prognosis. Grade 3 (G3 or high-grade) endometrioid endometrial carcinomas remain a clinical dilemma, with some tumors behaving as the low-grade counterparts and others presenting a more aggressive behavior. Objectives. To determine the association between POLE mutational status and the overall-s...

The PALliative MUlticenter Study in Intensive Care (PalMuSIC). Results From a M...

Objective: Frailty is a clinically recognizable state of increased vulnerability common in critical medicine. When underrecognized, it may lead to invasive treatments that do not serve the patients’ best interest. Our aim was to evaluate the use of both palliative care consultation and invasive interventions in frail patients admitted to Intensive Care Units in Portugal. Methods: This was a prospective, observa...

Anecdotal Response to Amphotericin in a Patient with Probable Susac Syndrome: I...

Susac syndrome is a rare, probably immune-mediated endotheliopathy presenting with encephalopathy, sensorineural hearing loss and retinal arterial occlusions. A 33-year-old female with Susac syndrome was worsening despite high-dose steroids so a brain biopsy was performed which suggested a possible fungal infection. Treatment with amphotericin B resulted in prompt reversal of symptoms and radiological findings,...

Transient Hepatic Elastography and Detection of Clinically Significant Esophage...

Introduction: Esophageal varices (EV) are a complicationof portal hypertension, and its rupture is associated witha high mortality rate. The use of non-invasive diagnosticmethods, including hepatic elastography, have been underinvestigation.Aim: Evaluate the usefulness of transient hepatic elastographyas a non-invasive test for the prediction of presenceof EV, to avoid systematic screening with esophagogastrodu...

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