102 documents found, page 1 of 11
Modeling microgravity using clinorotation in a microfluidic environment: a nume...
Fernandes, João; Machado, Dara; Minas, Graça; Catarino, Susana Oliveira; Pinho, DianaMicrogravity simulation is essential for studying particle dynamics in space-related applications where traditional gravitational effects are absent. This study presents a numerical investigation of particle behavior in a clinostat-driven microfluidic channel, aiming to simulate microgravity conditions. A computational model was developed in COMSOL Multiphysics to analyze the impact of channel size, particle di...
Low-cost photoacoustic system for biomedical applications
Ferreira, João Filipe SObreiro; Pinto, Vânia Cristina Gonçalves; Matos, Tiago; Catarino, Susana Oliveira; Minas, Graça; Sousa, Paulo Jorge TeixeiraRecently, the field of photoacoustic (PA) imaging has garnered significant attention due to its ability to provide high-resolution images and real-time monitoring of biological tissues. However, PA systems have relied on expensive and complex laser sources and detection mechanisms, limiting their accessibility for widespread use in both clinical and research settings. So, this work aims to address these limitat...
Models for light propagation in the head: trends and implementation of Finite E...
Fernandes, Filipa Gracinda Silva; Silva, Filipe Samuel; Sousa, Nuno; Carvalho, Óscar Samuel Novais; Catarino, Susana OliveiraThe simulation of light propagation in the head tissues has become of interest due to its applicability in transcranial photobiomodulation (tPBM). In silico studies appear as an effective way to research tPBM dosimetry and understand the light reach in the head tissues, as well as potential issues regarding tissue heating. Nonetheless, these computer models are still very simple and come with several limitation...
Numerical and experimental analysis of mixing efficiency in passive micromixers...
Ferreira, Filipe Maurício Santos; Sousa, Paulo Jorge Teixeira; Minas, Graça; Lima, Rui Alberto Madeira Macedo; Pinto, Vânia Cristina GonçalvesPassive micromixers play a critical role in microfluidic applications, particularly in lab-on-a-chip devices, since they do not require external energy input, being simpler, cheaper and portable. This paper reports the mixing efficiency by numerical simulation (using COMSOL Multiphysics) and by experimental validation of two 2D polydimethylsiloxane micromixer geometries. The tested flow rate ratios, 1:1, 1:4 an...
Unraveling the potential of transcranial photobiomodulation and ultrasound stim...
Fernandes, Nuno Alexandre Tavares Campos; Catarino, Susana Oliveira; Carvalho, Óscar Samuel NovaisThe human brain is the most sophisticated and the finest processing unit ever designed, but mental and neurological disorders are an imminent threat to its functioning. Indeed, brain disorders comprise one of the most challenging health issues of modern society due to their tremendous health, social, and economic impact. However, pharmacological therapies face a physical obstacle – the blood-brain barrier (BBB)...
Experimental and in silico models for studying light propagation in the head
Fernandes, Filipa Gracinda Silva; Silva, Filipe Samuel; Sousa, Nuno; Carvalho, Óscar Samuel Novais; Catarino, Susana OliveiraTranscranial photobiomodulation (tPBM) is an alternative therapy to conventional approaches, with clinical studies that show promising results for the treatment of several neurological pathologies, such as stroke and dementia related conditions. Despite its potential, the optimal light parameters and dosimetry for effective tPBM therapy remain uncertain, with most literature on this topic highlighting the need ...
Optimizing acoustic pressure fields in SAW microfluidic devices: A numerical st...
Amorim, Débora; Dinis, Hugo Daniel Costa; Minas, Graça; Sousa, Patrícia C.; Abreu, Carlos; Catarino, Susana OliveiraSurface acoustic wave-based microfluidic devices have gained substantial attention for their effectiveness in manipulating, detecting, and quantifying biological samples. These systems utilize interdigitated transducers deposited on piezoelectric substrates to generate acoustic fields within microchannels. This study presents a comparative analysis of acoustic pressure fields generated using different piezoelec...
Synthetic data generation using machine learning algorithms for enhanced Type 2...
Fadlelmoula, Ahmed; Torres, Helena; Catarino, Susana Oliveira; Minas, Graça; Carvalho, VitorStrict privacy regulations in healthcare limit access to patient data for research and predictive modeling. To address this, the study explores synthetic data as a privacy-preserving alternative that also enhances dataset size and diversity. Using machine learning-based generative models, Generative Adversarial Networks (GANs) and Autoencoders (AEs) the researchers created synthetic tabular data to improve type...
Editorial: insights in micro- and nano-fluidics
Damiati, Samar; Catarino, Susana Oliveira; Xuan, XiangchunThere is an increasing demand to explore various aspects of microfluidics, nanofluidics, and lab-on-a-chip technologies, as these fields hold significant promise for advancing future scientific and industrial applications. One key advantage of microfluidic and nanofluidic systems is their cost-effectiveness and environmental sustainability, primarily due to the reduction in reagent consumption and waste generat...
Modelling the heat distribution in organ-on-a-chip systems using integrated mic...
Ferreira, Gabriel Malheiro; Sousa, Patrícia C.; Catarino, Susana Oliveira; Minas, Graça[Excerpt] Microfluidic systems with integrated heating transducers are of growing interest for applications in biochemical sensing, lab-on-a-chip and organ-on-a-chip (OoC) technologies [1]. Particularly, in OoC systems, temperature monitoring is crucial to maintain the cultured cells in a well-defined microenvironment for proper growth [2]. This monitoring can be achieved through temperature control systems com...