2 documents found, page 1 of 1
Genetic Variants of the MGAT5 Gene Are Functionally Implicated in the Modulatio...
Pereira, MS; Durães, C; Catarino, TA; Costa, JL; Cleynen, I; Novokmet, M; Krištic, J; Štambuk, J; Conceição-Neto, N; Machado, JC; Marcos-Pinto, ROBJECTIVES: The impact of genetic variants (single nucleotide polymorphisms [SNPs]) in the clinical heterogeneity of ulcerative colitis (UC) remains unclear. We showed that patients with UC exhibit a deficiency in MGAT5 glycogene transcription in intestinal T cells associated with a hyperimmune response. Herein, we evaluated whether MGAT5 SNPs might functionally impact on T cells glycosylation and plasma IgG gl...
Preventing E-cadherin aberrant N-glycosylation at Asn-554 improves its critical...
Carvalho, S; Catarino, TA; Dias, A; Kato, M; Almeida, A; Hessling, B; Figueiredo, J; Gärtner, F; Sanches, J; Ruppert, T; Miyoshi, E; Pierce, ME-cadherin is a central molecule in the process of gastric carcinogenesis and its posttranslational modifications by N-glycosylation have been described to induce a deleterious effect on cell adhesion associated with tumor cell invasion. However, the role that site-specific glycosylation of E-cadherin has in its defective function in gastric cancer cells needs to be determined. Using transgenic mice models and ...