Encontrados 15 documentos, a visualizar página 1 de 2
Antimicrobial and antitumor activity of S-methyl dithiocarbazate Schiff base zi...
Gomes, Filipa Ramilo; Addis, Yemataw; Tekamo, Israel; Cavaco, Isabel; Campos, Débora L.; Pavan, Fernando R.; Gomes, Clara S.B.; Brito, VanessaSchiff bases (SB) obtained from S-methyl dithiocarbazate and aromatic aldehydes: salicylaldehyde (H2L1), o-vanillin (H2L2), pyridoxal (H2L3) and 2,6-diformyl-4-methylphenol (H3L4), and their corresponding Zn(II)-complexes (1-4), are synthesized. All compounds are characterized by elemental analyses, infrared, UV-Vis, nuclear magnetic resonance spectroscopy and mass spectrometry. The structures of H2L2 and [Zn2(...
Antimicrobial and antitumor activity of S-methyl dithiocarbazate Schiff base zi...
Ramilo-Gomes, Filipa; Addis, Yemataw; Tekamo, Israel; Cavaco, Isabel; Campos, Débora L. [UNESP]; Pavan, Fernando R. [UNESP]; Gomes, Clara S.B.Made available in DSpace on 2021-06-25T11:09:35Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-03-01; Schiff bases (SB) obtained from S-methyl dithiocarbazate and aromatic aldehydes: salicylaldehyde (H2L1), o-vanillin (H2L2), pyridoxal (H2L3) and 2,6-diformyl-4-methylphenol (H3L4), and their corresponding Zn(II)-complexes (1–4), are synthesized. All compounds are characterized by elemental analyses, inf...
Therapeutic potential of vanadium complexes with 1,10-phenanthroline ligands, q...
Nunes, Patrique; Correia, Isabel; Cavaco, Isabel; Marques, Fernanda; Pinheiro, Teresa; Avecilla, Fernando; Pessoa, Joao Costa(VO)-O-IV-complexes formulated as [(VO)-O-IV(OSO3)(phen)(2)] (1) (phen = 1,10-phenanthroline), [(VO)-O-IV(OSO3) (Me(2)phen)(2)] (2) (Me(2)phen = 4,7-dimethyl-1,10-phenanthroline) and [(VO)-O-IV(OSO3)(amphen)(2)] (3) (amphen = 5-amino-1,10-phenanthroline) were prepared and stability in cell incubation media evaluated. Their cytotoxicity was determined against the A2780 (ovarian), MCF7 (breast) and PC3 (prostate)...
Cytotoxicity of Cryptosula zavjalovensis Kubanin extract against Breast Cancer ...
Gonzaga, Loveille Jun; Cavaco, Isabel; Fortunato, HelenaThe marine environment is an abundant source of diverse biologically active compounds that demonstrate great potential applications in pharmaceutics and medicine. Although novel biologically active secondary metabolites can be potentially found in bryozoans, there have been a few studies on these organisms. Bryozoans are sessile colonial animals commonly found in great diversity in shallow waters. In this study...
Antimicrobial and antitumor activity of S-methyl dithiocarbazate Schiff base zi...
Ramilo-Gomes, Filipa; Alemu, Yemataw; Tekamo, Israel; Cavaco, Isabel; Campos, Débora L.; Pavan, Fernando R.; Gomes, Clara S.B.; Brito, VanessaSchiff bases (SB) obtained from S-methyl dithiocarbazate and aromatic aldehydes: salicylaldehyde (H2L1), o-vanillin (H2L2), pyridoxal (H2L3) and 2,6-diformyl-4-methylphenol (H3L4), and their corresponding Zn(II)-complexes (1-4), are synthesized. All compounds are characterized by elemental analyses, infrared, UV-Vis, nuclear magnetic resonance spectroscopy and mass spectrometry. The structures of H2L2 and [Zn2(...
Strategies and approaches of companies in Portugal and Spain in complying with ...
Talampas, Sheila, I; Cavaco, Isabel; Sainz, DanielThe implementation of the Registration, Evaluation, Authorization, and Restriction of Chemicals (REACH) regulation had been viewed to be the most ambitious chemicals legislation in the world and had placed a great challenge among the European Union (EU) member states. While government regulatory agencies were focused on how they can successfully implement and enforce the legislation, the industries' concern was...
Exploring the therapeutic potential of Cu(II)-complexes with ligands derived fr...
Nunes, Patrique; Marques, Fernanda; Cavaco, Isabel; Pessoa, Joao Costa; Correia, IsabelThree new copper(II) complexes formulated as [Cu(L)(X)], where X = H2O or Cl and H2L is a Schiff base (H2L1,2) or its reduced version ((H3LCl)-Cl-3) derived from pyridoxal, are prepared, as well as two ternary complexes [Cu(L) (phen)] also containing 1,10-phenanthroline. All compounds are characterized by the usual techniques: elemental analyses, ESI mass spectrometry, UV-Vis absorption, FTIR and EPR spectrosco...
Copper Complexes with 1,10-Phenanthroline Derivatives: Underlying Factors Affec...
Nunes, Patrique; Correia, Isabel; Marques, Fernanda; Matos, Antonio Pedro; dos Santos, Margarida M. C.; Azevedo, Cristina G.; Capelo, Jose-LuisThe interpretation of in vitro cytotoxicity data of Cu(II)-1,10-phenanthroline (phen) complexes normally does not take into account the speciation that complexes undergo in cell incubation media and its implications in cellular uptake and mechanisms of action. We synthesize and test the activity of several distinct Cu(II)-phen compounds; up to 24 h of incubation, the cytotoxic activity differs for the Cu comple...
Exploring the cytotoxic activity of new phenanthroline salicylaldimine Zn(II) c...
Matos, Cristina; Addis, Yemataw; Nunes, Patrique; Barroso, Sónia; Alho, Irina; Martins, Marta; Matos, António P.A.; Marques, Fernanda; Cavaco, IsabelZinc(II) complexes bearing N-salicylideneglycinate (Sal-Gly) and 1,10-phenanthroline (phen) or phenanthroline derivatives [NN = 5-chloro-1,10-phenanthroline, 5-amine-1,10-phenanthroline (amphen), 4,7-diphenyl-1,10-phenanthroline (Bphen) and 5,6-epoxy-5,6-dihydro-1,10-phenanthroline] are synthesized. Complexes formulated as [Zn(NN)2(H2O)2]2+(NN = phen and amphen), are also prepared. The cytotoxicity of the compo...
Naphthoylhydrazones: coordination to metal ions and biological screening
Ribeiro, Nadia; Galvao, Adelino M.; Gomes, Clara S. B.; Ramos, Helena; Pinheiro, Rute; Saraiva, Lucilia; Ntungwe, Epole; Isca, Vera; Rijo, PatriciaWe report the synthesis of 3-hydroxyl-2-naphthoylhydrazones containing pyrrole (HL1), furane (HL2) and thiophene (HL3) moieties and their V(IV)O-, Cu(II)- and Zn(II)-complexes. All compounds are characterized by the usual analytical techniques and coordination of the ligands to the metal ions is discussed based on spectroscopic data (FTIR, UV-vis, EPR and NMR) as well as CAMB3LYP DFT/TDDFT calculations, indicat...