5 documents found, page 1 of 1
Primary Pulmonary Tumor in an Adolescent
Rodrigues, L; Domingues, R; Amaral, D; Cavaco, JPrimary lung tumors in the pediatric age group are rare, histologically diverse and have different therapeutic approaches. The inflammatory myofibroblastic tumor of the lung accounts for 0.04% - 1.2% of all lung tumors, is more common in children and young adults and its etiology is unknown. The diagnosis is difficult as clinical and radiological findings are highly variable. We report a case of a 15-year-old a...
The effect of premature termination codon mutations on CFTR mRNA abundance in h...
Clarke, LA; Awatade, NT; Felício, VM; Silva, IA; Calucho, M; Pereira, L; Azevedo, P; Cavaco, J; Barreto, C; Bertuzzo, C; Gartner, S; Beekman, JA major challenge in cystic fibrosis (CF) research is applying mutation-specific therapy to individual patients with diverse and rare CF transmembrane conductance regulator (CFTR) genotypes. Read-through agents are currently the most promising approach for Class I mutations that introduce premature termination codons (PTCs) into CFTR mRNA. However, variations in degradation of PTC containing transcripts by nons...
The Burkholderia Cenocepacia OmpA-Like Protein BCAL2958: Identification, Charac...
Sousa, S; Morad, M; Feliciano, JR; Pita, T; Nady, S; El-Hennamy, R; Abdel-Rahman, M; Cavaco, J; Pereira, L; Barreto, C; Leitão, JHRespiratory infections by bacteria of the Burkholderia cepacia complex (Bcc) remain an important cause of morbidity and mortality among cystic fibrosis patients, highlighting the need for novel therapeutic strategies. In the present work we have studied the B. cenocepacia protein BCAL2958, a member of the OmpA-like family of proteins, demonstrated as highly immunogenic in other pathogens and capable of elicitin...
Cystic Fibrosis, Atopy, Asthma and ABPA
Antunes, J; Fernandes, A; Borrego, LM; Leiria-Pinto, P; Cavaco, JThe role of atopy on cystic fibrosis (CF) progression remains unclear but evidence suggests that it may influence the appearance of co-morbid conditions such as CF asthma or allergic bronchopulmonary aspergillosis (ABPA). Recognising asthma in patients with CF is not always easy but the identification of atopic markers favours the diagnosis. Physicians should be aware of this fact in order to achieve a better c...
Tuberculose Infantil — Anos 90. Revisão Casuística de 5 Anos
Lage, MJ; Cruz, C; Chaves, F; Cavaco, J; Lopes, B; Carapau, JÉ apresentada a revisão de 204 casos de tuberculose doença diagnosticados e tratados no Hospital de D. Estefânia num período de 5 anos (1990-1994). Refira-se, nos casos estudados (204), a maior percentagem de crianças no grupo etário dos 5 aos 14 anos (67%), uma incidência de 32% para a raça negra e um predomínio nas classes sociais mais desfavorecidas, contribuindo o concelho da Amadora com a maior percentagem...