2 documents found, page 1 of 1
Intracoronary Delivery of Human Mesenchymal/Stromal Stem Cells: Insights from C...
Fiarresga, A; Mata, M; Cavaco-Gonçalves, S; Selas, M; Simões, I; Oliveira, E; Carrapiço, B; Cardim, N; Cabral, J; Cruz Ferreira, R; Silva, CBACKGROUND: Mesenchymal stem/stromal cells have unique properties favorable to their use in clinical practice and have been studied for cardiac repair. However, these cells are larger than coronary microvessels and there is controversy about the risk of embolization and microinfarctions, which could jeopardize the safety and efficacy of intracoronary route for their delivery. The index of microcirculatory resis...
Invasive Assessment of the Coronary Microcirculation Using the Index of Microci...
Fiarresga, A; Selas, M; Oliveira, E; Cavaco-Gonçalves, S; Cacela, D; Carrapiço, B; Cardim, N; Cruz Ferreira, RINTRODUCTION: The index of microcirculatory resistance (IMR) enables/provides quantitative, invasive, and real-time assessment of coronary microcirculation status. AIMS: The primary aim of this study was to validate the assessment of IMR in a large animal model, and the secondary aim was to compare two doses of intracoronary papaverine, 5 and 10 mg, for induction of maximal hyperemia and its evolution over time...