6 documents found, page 1 of 1
Molecular Typing, Virulence Traits and Antimicrobial Resistance of Diabetic Foo...
Mottola, C; Semedo-Lemsaddek, T; Mendes, JJ; Melo-Cristino, J; Tavares, L; Cavaco-Silva, P; Oliveira, MDiabetes mellitus is a major chronic disease that continues to increase significantly. One of the most important and costly complications of diabetes are foot infections that may be colonized by pathogenic and antimicrobial resistant bacteria, harboring several virulence factors, that could impair its successful treatment. Staphylococcus aureus is one of the most prevalent isolate in diabetic foot infections, t...
Susceptibility Patterns of Staphylococcus Aureus Biofilms in Diabetic Foot Infe...
Mottola, C; Matias, C; Mendes, JJ; Melo-Cristino, J; Tavares, L; Cavaco-Silva, P; Oliveira, MBACKGROUND: Foot infections are a major cause of morbidity in people with diabetes and the most common cause of diabetes-related hospitalization and lower extremity amputation. Staphylococcus aureus is by far the most frequent species isolated from these infections. In particular, methicillin-resistant S. aureus (MRSA) has emerged as a major clinical and epidemiological problem in hospitals. MRSA strains have t...
In Vitro Design of a Novel Lytic Bacteriophage Cocktail with Therapeutic Potent...
Mendes, JJ; Leandro, C; Mottola, C; Barbosa, R; Silva, F; Oliveira, M; Vilela, C; Melo-Cristino, J; Górski, A; Pimentel, M; São-José, C; Cavaco-Silva, PIn patients with diabetes mellitus, foot infections pose a significant risk. These are complex infections commonly caused by Staphylococcus aureus, Pseudomonas aeruginosa and Acinetobacter baumannii, all of which are potentially susceptible to bacteriophages. Here, we characterized five bacteriophages that we had determined previously to have antimicrobial and wound-healing potential in chronic S. aureus, P. ae...
Evolution of the Human Immunodeficiency Virus Type 2 Envelope in the First Year...
Rocha, C; Calado, R; Borrego, P; Marcelino, JM; Bártolo, I; Rosado, L; Cavaco-Silva, P; Gomes, P; Família, C; Quintas, A; Skar, H; Leitner, TBackground: Differently from HIV-1, HIV-2 disease progression usually takes decades without antiretroviral therapy and the majority of HIV-2 infected individuals survive as elite controllers with normal CD4+ T cell counts and low or undetectable plasma viral load. Neutralizing antibodies (Nabs) are thought to play a central role in HIV-2 evolution and pathogenesis. However, the dynamic of the Nab response and r...
Clinical and Bacteriological Survey of Diabetic Foot Infections in Lisbon
Mendes, JJ; Marques-Costa, A; Vilela, C; Neves, J; Candeias, N; Cavaco-Silva, P; Melo-Cristino, JAIMS: An epidemiological survey of diabetic foot infections (DFIs) in Lisbon, stratifying the bacterial profile based on patient demographical data, diabetic foot characteristics (PEDIS classification), ulcer duration and antibiotic therapy. METHODS: A transversal observational multicenter study, with clinical data collection using a structured questionnaire and microbiological products (aspirates, biopsies or ...
Baseline Susceptibility of Primary HIV-2 to Entry Inhibitors
Borrego, P; Calado, R; Marcelino, JM; Bártolo, I; Rocha, C; Cavaco-Silva, P; Doroana, M; Antunes, F; Maltez, F; Caixas, U; Barroso, H; Taveira, NBACKGROUND: The baseline susceptibility of primary HIV-2 to maraviroc (MVC) and other entry inhibitors is currently unknown. METHODS: The susceptibility of 19 HIV-2 isolates obtained from asymptomatic and AIDS patients and seven HIV-1 clinical isolates to the fusion inhibitors enfuvirtide (ENF) and T-1249, and to the coreceptor antagonists AMD3100, TAK-779 and MVC, was measured using a TZM-bl cell-based assay. ...