3 documents found, page 1 of 1
Peripheral biomarkers to diagnose obstructive sleep apnea in adults: A systemat...
Gaspar, LS; Santos-Carvalho, A; Santos, B; Carvalhas-Almeida, C; Barros-Viegas, AT; Oliveiros, B; Donato, H; Santos, C; Moita, J; Cavadas, C; Álvaro, ARBackground: Obstructive Sleep Apnea (OSA) has been recognized as a major health concern worldwide, given its increasing prevalence, difficulties in diagnosis and treatment, and impact on health, economy, and society. Clinical guidelines highlight the need of biomarkers to guide OSA clinical decision-making, but so far, without success. In this systematic review and meta-analysis, registered on the International...
The NAD+-dependent deacetylase SIRT2 attenuates oxidative stress and mitochondr...
Lemos, V; de Oliveira, RM; Naia, L; Szegö, É; Ramos, E; Pinho, S; Magro, F; Cavadas, C; Rego, AC; Outeiro, TF; Gomes, PInsulin resistance is a major predictor of the development of metabolic disorders. Sirtuins (SIRTs) have emerged as potential targets that can be manipulated to counteract age-related diseases, including type 2 diabetes. SIRT2 has been recently shown to exert important metabolic effects, but whether SIRT2 regulates insulin sensitivity in hepatocytes is currently unknown. The aim of this study is to investigate ...
The Adenosinergic System in Diabetic Retinopathy
Vindeirinho, J.; Santiago, A. R.; Cavadas, C; Ambrósio, António F.; Santos, P. F.The neurodegenerative and inflammatory environment that is prevalent in the diabetic eye is a key player in the development and progression of diabetic retinopathy. The adenosinergic system is widely regarded as a significant modulator of neurotransmission and the inflammatory response, through the actions of the four types of adenosine receptors (A1R, A2AR, A2BR, and A3R), and thus could be revealed as a poten...