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Biological evaluation of isoniazid derivatives as an anticancer class

Rodrigues, Felipe A. R.; Oliveira, Augusto C. A.; Cavalcante, Bruno C.; Pessoa, Claudia; Pinheiro, Alessandra C.; Souza, Marcus V. N. de

A series of thirty-two isoniazid derivatives have been evaluated for their activity against four human cancer cell lines with potent cytotoxicity (IC50 ranging from 0.61 to 3.36 μg/mL). The structure-activity relationship (SAR) analysis indicated the number, the positions, and the types of substituents attached to the aromatic ring as being critical factors for the biological activity. Briefly, we observed that...

Date: 2014   |   Origin: Oasisbr
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