17 documents found, page 1 of 2
Food products based on Cannabis extract: from “Brisadeiro” to searching for a t...
Delmiro, Josué de Araújo; Torres, Francisco Brenon de Oliveira; Almeida, Antonia Amanda Cardoso de; Ferreira, Paulo Michel PinheiroIntroduction. Cannabis-based edibles have become a lucrative and in-demand market. Despite not being legalized in Brazil, marijuana is found in oral preparations illegally marketed in the country and the search for these products has grown in recent years. The present study aims to gather data from the scientific literature on the physiology of the endocannabinoid system, effects of oral cannabis consumption, p...
Gum arabic and red propolis protecteting colorectal preneoplastic lesions in a ...
Braga, Vanessa Nogueira Lages; Juanes, Camila de Carvalho; Peres Júnior, Hélio de Souza; Sousa, José Robson de; Cavalcanti, Bruno CoêlhoPurpose: To evaluate red propolis, gum arabic and L-lysine activity on colorectal preneoplastic lesions induced by azoxymethane (AOM). Methods: The study featured 4 control groups (I-IV) and 4 experimental groups (V-VIII), totaling 48 rats. Once a week for 2 weeks, animals on control groups received saline, while animals in experimental groups received azoxymethane (15 mg/kg i.p.). The follow up along 16 weeks ...
Antifungal activity of palmatine against strains of Candida spp. resistant to a...
Campos, Rosana de Sousa; Silva, Cecília Rocha da; Andrade Neto, João Batista de; Sampaio, Letícia Serpa; Nascimento, Francisca Bruna Stefany Aires doThe incidence of fungal infections has increased and it is necessary to seek new antifungals that also act against resistant strains. Palmatine is a protoberberine alkaloid noteworthy for its various pharmacological properties, including antifungal properties. The objective of this study was to evaluate the activity of palmatine against Candida spp. strains resistant to azole in planktonic cells and biofilm, an...
In vitro evaluation of the curcumin against fluconazole-resistant strains of Ca...
Freitas, Daniel Domingues; Silva, Cecília Rocha da; Andrade Neto, João Batista de; Campos, Rosana de Sousa; Sampaio, Letícia SerpaThe isolates of Candida spp. and Cryptococcus neoformans were inhibited by curcumin, with different degrees of inhibition among species, with MICs ranging from 8-64 μg/mL. After exposure of the C. albicans strains to curcumin, it was observed a decrease in the number of viable cells and damage to cell membranes, the mitochondrial function of C. albicans cells appears to be affected after exposure to curcumin. O...
Gum arabic and red propolis protecteting colorectal preneoplastic lesions in a ...
Braga, Vanessa Nogueira Lages; Juanes, Camila de Carvalho; Peres Júnior, Hélio de Souza; Sousa, José Robson de; Cavalcanti, Bruno CoêlhoPurpose: To evaluate red propolis, gum arabic and L-lysine activity on colorectal preneoplastic lesions induced by azoxymethane (AOM). Methods: The study featured 4 control groups (I-IV) and 4 experimental groups (V-VIII), totaling 48 rats. Once a week for 2 weeks, animals on control groups received saline, while animals in experimental groups received azoxymethane (15 mg/kg i.p.). The follow up along 16 weeks ...
Berberine antifungal activity in fluconazole-resistant pathogenic yeasts : acti...
Silva, Anderson Ramos da; Andrade Neto, João Batista de; Silva, Cecília Rocha da; Campos, Rosana de Sousa; Silva, Rose Anny CostaThe incidence of fungal infections and, in particular, the incidence of fungal antibiotic resistance, which is associated with bio- film formation, have significantly increased, contributing to morbidity and mortality. Thus, new therapeutic strategies need to be developed. In this context, natural products have emerged as a major source of possible antifungal agents. Berberine is a pro- toberberine-type isoquin...
Evaluation of synergistic effect of kaurenoic acid derivatives with fluconazole...
Andrade Neto, João Batista de; Silva, Cecília Rocha da; Campos, Rosana de Sousa; Nascimento, Francisca Bruna Stefany Aires do; Sampaio, Letícia SerpaCandida species are the fourth most common cause of nosocomial bloodstream infections in the United States and the fifth to tenth most common causative pathogen in European studies Although C. albicans remains the most common fungal isolate recovered from blood, recent reports indicate a trend towards an increasing prevalence of infections caused by species of Candida other than C. albicans which are associated...
Bioactive extracts and chemical constituents of two endophytic strains of Fusar...
Nascimento, Andréa Mendes do; Conti, Raphael; Turatti, Izabel Cristina Casanova; Cavalcanti, Bruno Coêlho; Lotufo, Leticia Veras Costa; Pessoa, CláudiaEthyl acetate extracts of cultures grown in liquid Czapek and on solid rice media of the fungal endophyte Fusarium oxysporum SS46 isolated from the medicinal plant Smallanthus sonchifolius (Poepp.) H. Rob., Asteraceae, exhibited considerable cytotoxic activity when tested in vitro against human cancer cells. Chromatographic separation yielded anhydrofusarubin (1) and beauvericin (2) that were identified based o...
Synergistic effect of the flavonoid catechin, quercetin, or epigallocatechin ga...
Silva, Cecília Rocha da; Andrade Neto, João Batista de; Campos, Rosana de Sousa; Figueiredo, Narjara Silvestre; Sampaio, Letícia SerpaFlavonoids are a class of phenolic compounds commonly found in fruits, vegetables, grains, flowers, tea, and wine. They differ in their chemical structures and characteristics. Such compounds show various biological functions and have antioxidant, antimicrobial, anti-inflammatory, and antiapoptotic properties. The aim of this study was to evaluate the in vitro interactions of flavonoids with fluconazole against...
Induction of G2/M arrest, caspase activation and apoptosis by a-santonin deriva...
Ferreira, José Roberto Oliveira; Cavalcanti, Bruno Coêlho; Costa, Patricia Marçal da; Arantes, Francisco Frederico Perlinson deSesquiterpene lactones (SLs) are natural products with a variety of biological activities. Previously, we demonstrated the cytotoxic effects of three new a-santonin derivatives on different tumor cell lines with low toxic effects upon peripheral human leukocytes. Here, we evaluated the mechanism of action triggered by these derivatives. HL-60 cell cycle determined after 24 h treatment revealed a significant inh...