7 documents found, page 1 of 1
Chitosan Nanoparticles Loaded with Carvacrol and Carvacryl Acetate for Improved...
André,Weibson P. P.; Paiva Jr.,José R.; Cavalcante,Géssica S.; Ribeiro,Wesley L. C.; Araújo Filho,José V. de; Cavalcanti,Bruno C.; Morais,Selene M. deCarvacrol (CV) and carvacryl acetate (CVA) are bioactive compounds that have anthelmintic action and the nanoencapsulation may be an alternative to potentialize their efficacy. The aim of this work was to nanoencapsulate CV and CVA using chitosan/gums and evaluate cytotoxicity and the anthelmintic activity. A 24 factorial experimental design was performed to determine the influence of gum type (arabic or chichá...
Potent antileukemic action of naphthoquinoidal compounds: evidence for an intri...
Cavalcanti,Bruno C.; Cabral,Igor O.; Rodrigues,Felipe A. R.; Barros,Francisco W. A.; Rocha,Danilo D.; Magalhães,Hemerson I. F.; Moura,Dinara J.The current study describes that nor-β-lapachone and its arylamino derivatives, iodinated and methylated naphthoquinones and nor-β-lapachone-based 1,2,3-triazoles exhibited pronounced cytotoxic effects against four human leukemia cell lines (HL-60, K562, Molt-4 and Jurkat). Nor-β-lapachones arylamino substituted with potent activity were identified, revealing themselves as potential prototypes against tumor cel...
Bioactive extracts and chemical constituents of two endophytic strains of Fusar...
Nascimento,Andréa M. do; Conti,Raphael; Turatti,Izabel C. C.; Cavalcanti,Bruno C.; Costa-Lotufo,Letícia V.; Pessoa,Cláudia; Moraes,Manoel O. deEthyl acetate extracts of cultures grown in liquid Czapek and on solid rice media of the fungal endophyte Fusarium oxysporum SS46 isolated from the medicinal plant Smallanthus sonchifolius (Poepp.) H. Rob., Asteraceae, exhibited considerable cytotoxic activity when tested in vitro against human cancer cells. Chromatographic separation yielded anhydrofusarubin (1) and beauvericin (2) that were identified based o...
Evaluating methods for the isolation of marine-derived fungal strains and produ...
Kossuga,Miriam H.; Romminger,Stelamar; Xavier,Camila; Milanetto,Marília C.; Valle,Milene Z. do; Pimenta,Eli F.; Morais,Raquel P.; Carvalho,Erica deIn the present investigation we evaluate methods for the isolation and growth of marine-derived fungal strains in artificial media for the production of secondary metabolites. Inoculation of marine macroorganisms fragments in Petri dishes proved to be the most convenient procedure for the isolation of the largest number of strains. Among the growth media used, 3% malt extract showed the best result for strains ...
Antibiotic, cytotoxic and enzyme inhibitory activity of crude extracts from Bra...
Seleghim,Mirna H. R.; Lira,Simone P.; Kossuga,Miriam H.; Batista,Tatiana; Berlinck,Roberto G. S.; Hajdu,Eduardo; Muricy,Guilherme; Rocha,Rosana M. daHerein we present the results of a screening with 349 crude extracts of Brazilian marine sponges, ascidians, bryozoans and octocorals, against 16 strains of susceptible and antibiotic-resistant bacteria, one yeast (Candida albicans), Mycobacterium tuberculosis H37Rv, three cancer cell lines MCF-7 (breast), B16 (murine melanoma ) and HCT8 (colon), and Leishmania tarentolae adenine phosphoribosyl transferase (L-A...
Produtos naturais da ascídia Botrylloides giganteum, das esponjas Verongula gig...
Granato,Ana Claudia; Oliveira,Jaine H. H. L. de; Seleghim,Mirna H. R.; Berlinck,Roberto G. S.; Macedo,Mario L.; Ferreira,Antonio G.; Rocha,Rosana M. daTwo new marine metabolites, 3Z, 6Z, 9Z-dodecatrien-1-ol (1) from the ascidian Botrylloides giganteum and 4H-pyran-2ol acetate from the sponge Ircinia felix (4) are herein reported. The known bromotyrosine compounds, 2-(3,5-dibromo-4-methoxyphenyl)-N,N,N-dimethylethanammonium (2) and 2,6-dibromo-4-(2-(trimethylammonium)ethyl)phenol (3), have been isolated from the sponge Verongula gigantea. Serotonin (5) is repo...
Synthesis and biological evaluation of new salicylate macrolactones from anacar...
Logrado,Lúcio P. L.; Silveira,Dâmaris; Romeiro,Luiz A. S.; Moraes,Manoel O. de; Cavalcanti,Bruno C.; Costa-Lotufo,Letícia V.; Pessoa,Cláudia do ÓIn connection with our ongoing investigation in the search for new bioactive compounds using non-isoprenoid phenolic lipids from Anacardium occidentale as starting material, we describe the synthesis and cytotoxicity screening of some novel salicylate macrolactones prepared from anacardic acids, the major constitutents of natural cashew nut-shell liquid (CNSL).