6 documents found, page 1 of 1
Natalizumab treatment modulates Peroxisome Proliferator-Activated Receptors exp...
Ferret-Sena, Véronique; Silva, Alexandra Maia e; Sena, Armando; Cavaleiro, Inês; Vale, José; Derudas, Bruno; Chinetti-Gbaguidi, Giulia; Staels, BartPeroxisome Proliferator-Activated Receptors (PPAR) are transcription factors suggested to be involved in inflammatory lesions of autoimmune encephalomyelitis and multiple sclerosis (MS). Our objective was to assess whether Natalizumab (NTZ) therapy is associated with alterations of PPAR expression in MS patients. We analyzed gene expression of PPAR in peripheral blood mononuclear cells (PBMC) as well as blood i...
Arthritis induces early bone high turnover, structural degradation and mechanic...
Vidal, Bruno; Cascão, Rita; Vale, Ana Catarina; Cavaleiro, Inês; Vaz, Maria Fátima; Brito, José Américo Almeida; Canhão, Helena; Fonseca, João EuricoBACKGROUND: We have previously found in the chronic SKG mouse model of arthritis that long standing (5 and 8 months) inflammation directly leads to high collagen bone turnover, disorganization of the collagen network, disturbed bone microstructure and degradation of bone biomechanical properties. The main goal of the present work was to study the effects of the first days of the inflammatory process on the micr...
Rs266882 polymorphism analysis in KLK3 gene by RFLPPCR in cases of prostate cancer
Franco, Joana; Cavaleiro, Inês; Bernardes, Catarina; Ribeiro, Ana Clara; Silva, Alexandra Maia e"The prostate cancer (PC) is one of the most frequent neoplasia in men even though not the deadliest. Every year more than 1,1 million men are diagnose with PC worldwide. The principal risks factors are: age, diet, familiar predisposition, race and hormones. Gleason classification is use to graduate PC based upon the histologic pattern of tumoral growth. Additionally to this classification is use TNM that allow...
Arthritis induces early bone high turnover, structural degradation and mechanic...
Vidal, Bruno; Cascao, Rita; Vale, Ana Catarina; Cavaleiro, Inês; Vaz, Maria Fátima; Brito, José Américo Almeida; Canhao, Helena; Fonseca, João EuricoBackground: We have previously found in the chronic SKG mouse model of arthritis that long standing (5 and 8 months) inflammation directly leads to high collagen bone turnover, disorganization of the collagen network, disturbed bone microstructure and degradation of bone biomechanical properties. The main goal of the present work was to study the effects of the first days of the inflammatory process on the micr...
Vif- H3.3 interaction, a new Vif function?
Silva, Alexandra Maia e; Cavaleiro, Inês; Ribeiro, Ana Clara; Barahona, Isabel
Análise de polimorfismos no gene humano IGF-I
Sítima, Maria; Dourado-Santos, Tiago; Bernardes, Catarina; Cavaleiro, Inês; Silva, Alexandra Maia e