5 documents found, page 1 of 1
Application of human biomonitoring data to support policy development, raise aw...
Ubong, Dorothy; Stewart, Lorraine; Sepai, Ovnair; Knudsen, Lisbeth E.; Berman, Tamar; Reynders, Hans; Van Campenhout, Karen; Katsonouri, AndromachiMost countries have acknowledged the importance of assessing and quantifying their population’s internal exposure from chemicals in air, water, soil, food and other consumer products due to the potential health and economic impact. Human biomonitoring (HBM) is a valuable tool which can be used to quantify such exposures and effects. Results from HBM studies can also contribute to improving public health by prov...
Perceções da população portuguesa sobre biomonitorização humana segundo o inqué...
Namorado, Sónia; Louro, Henriqueta; Isidro, Glória; Cavaleiro, Rita; Moura, Isabel; Borges, Teresa; Virgolino, Ana; Santos, Osvaldo; Vicente, Joana LoboNo âmbito da Iniciativa Europeia em Biomonitorização Humana (HBM4EU) foi realizado um inquérito dirigido aos cidadãos europeus que pretendia recolher informação acerca das suas opiniões e perceções sobre a exposição a substâncias químicas, bem como sobre o que é a biomonitorização humana (BMH), por que é que ela é importante e qual o seu papel na saúde. Em Portugal responderam ao inquérito 669 indivíduos, a mai...
PD-1 and its ligand PD-L1 are progressively up-regulated on CD4 and CD8 T-cells...
Tendeiro, R; Foxall, Russell B.; Baptista, António P.; Pinto, Francisco; Soares, Rui S.; Cavaleiro, Rita; Valadas, Emília; Gomes, PerpétuaObjective: Hyper-immune activation is a main determinant of HIV disease progression, potentially counter-acted by T-cell inhibitory pathways. Here we investigated, for the first time, inhibitory molecules in HIV-2 infection, a naturally occurring attenuated form of HIV disease, associated with reduced viremia and very slow rates of CD4 T-cell decline. Design: Programmed death (PD)-1/PD-L1, an important pathway ...
Cell-associated viral burden provides evidence of ongoing viral replication in ...
Soares, Rui S.; Tendeiro, Rita; Foxall, Russell B.; Baptista, António P.; Cavaleiro, Rita; Gomes, Perpétua; Camacho, Ricardo; Valadas, EmíliaViremia is significantly lower in HIV-2 than in HIV-1 infection, irrespective of disease stage. Nevertheless, the comparable proviral DNA burdens observed for these two infections indicate similar numbers of infected cells. Here we investigated this apparent paradox by assessing cell-associated viral replication. We found that untreated HIV-1-positive (HIV-1(+)) and HIV-2(+) individuals, matched for CD4 T cell ...
Dendritic cell differentiation and maturation in the presence of HIV Type 2 env...
Cavaleiro, Rita; Baptista, Antonio P.; Foxall, Russell; Victorino, Rui; Sousa, Ana E.Dendritic cells (DCs) are fundamental for the initiation of immune responses and are important players in AIDS immunopathogenesis. Impairment of DC function may result from bystander effects of HIV-1 envelope proteins independently of direct HIV-1 infection. HIV-2 envelope proteins are thought to interact with a broader range of receptors than those of HIV-1, and have been shown to have T cell immunosuppressive...