46 documents found, page 1 of 5
Polymorphisms and haplotypes of TOLLIP and MUC5B are associated with susceptibi...
Mota, PC; Soares, ML; Ferreira, AC; Santos, RF; Cavaleiro Rufo, J; Vasconcelos, D; Carvalho, A; Guimarães, S; Vasques-Nóvoa, F; Cardoso, C; Melo, NIntroduction and Objectives: Hypersensitivity pneumonitis (HP) is an interstitial lung disease with diverse clinical features that can present a fibrotic phenotype similar to idiopathic pulmonary fibrosis (IPF) in genetically predisposed individuals. While several single nucleotide polymorphisms (SNPs) have been associated with IPF, the genetic factors contributing to fibrotic HP (fHP) remain poorly understood....
Polymorphisms and haplotypes of TOLLIP and MUC5B are associated with susceptibi...
Mota, P.C.; Soares, M.L.; Ferreira, A.C.; F. Santos, Rita; Cavaleiro Rufo, J; Vasconcelos, D.; Carvalho, A.; Guimarães, S.; Vasques-Novo, F.Hypersensitivity pneumonitis (HP) is an interstitial lung disease with diverse clinical features that can present a fibrotic phenotype similar to idiopathic pulmonary fibrosis (IPF) in genetically predisposed individuals. While several single nucleotide polymorphisms (SNPs) have been associated with IPF, the genetic factors contributing to fibrotic HP (fHP) remain poorly understood. This study investigated the ...
Editorial comments on "Multiarray screening identifies plasma proteins associat...
Cavaleiro Rufo, J; Chauhan, J; Kalayci, Ö; Eigenmann, P
Issue 2 - "Update on adverse respiratory effects of indoor air pollution" Part ...
Cavaleiro Rufo, J; Annesi-Maesano, I; Carreiro-Martins, P; Moreira, A; Sousa, AC; Pastorinho, MR; Neuparth, N; Taborda-Barata, LObjective To quantify the impact of different air pollutants on respiratory health based on robust estimates based on international data and to summarise the evidence of associations between indoor exposure to those pollutants and respiratory morbidity in the Portuguese population. Results Several systematic reviews and meta-analyses (MA) at the world level demonstrate the impact of indoor air quality on respir...
Component-resolved diagnosis in childhood and prediction of asthma in early ado...
Farraia, M; Mendes, FC; Sokhatska, O; Rama, T; Severo, M; Custovic, A; Cavaleiro Rufo, J; Barros, H; Moreira, A"Introduction Component-resolved diagnosis (CRD) has been decisive in exploring the mechanisms of IgE sensitization, but the predictive ability to detect asthma has not been addressed. We aim to develop and evaluate the performance of a personalized predictive algorithm for asthma that integrates information on allergic sensitization using CRD. Methods One thousand one hundred one twenty-five children from the ...
Diet quality, asthma and airway inflammation in school-aged children
Rodrigues, M; de Castro Mendes, F; Paciência, I; Barros, Renata; Padrão, Patrícia; Cavaleiro Rufo, J; Cavaleiro, D; Delgado, L; Moreira, A
Does the Mediterranean Dietary Pattern Promote Lower Sodium Urinary Excretion i...
Rodrigues, M; Castro Mendes, F; Padrão, P; Delgado, L; Barros, R; Cavaleiro Rufo, J; Silva, D; Moreira, A; Moreira, PAn adequate sodium intake is related to various health benefits. Parallelly, the Mediterranean diet (MD) is a dietary pattern known for its many positive impacts on health. Nonetheless, the association between adherence to the MD and sodium urinary excretion is scarce, even more in children. This study aimed to assess the association between MD adherence and the excretion of sodium, as a proxy of intake. This c...
Cost-effectiveness analysis of grass pollen specific immunotherapy in children ...
Farraia, M; Paciência, I; Mendes, FC; Cavaleiro Rufo, J; Delgado, L; Moreira, ABackground. Cost-effectiveness studies evaluating allergen immunothera-py (AIT) in children are scarce. We aim to compare the cost-effectiveness of subcutaneous (SCIT) and sublingual immunotherapy (SLIT) against stan-dard-of-care (SOC) treatment in children with grass pollen allergic rhinitis. Methods. We created a Markov model to compare the three strategies over a 10-year horizon. SOC was the reference to cal...
Bone and Cytokine Markers Associated With Bone Disease in Systemic Mastocytosis
Rama, TA; Henriques, AF; Matito, A; Jara-Acevedo, M; Caldas, C; Mayado, A; Muñoz-González, JI; Moreira, A; Cavaleiro Rufo, J; García-Montero, ABackground Mastocytosis encompasses a heterogeneous group of diseases characterized by tissue accumulation of clonal mast cells, which frequently includes bone involvement. Several cytokines have been shown to play a role in the pathogenesis of bone mass loss in systemic mastocytosis (SM), but their role in SM-associated osteosclerosis remains unknown. Objective To investigate the potential association between ...
Sensitization trajectories to multiple allergen components in a population-base...
Farraia, M; Mendes, FC; Sokhatska, O; Severo, M; Cavaleiro Rufo, J; Barros, H; Moreira, ABackgroundThe characteristics of allergic sensitization profiles can differ between populations and geographic regions, contributing differently to the association with allergic diseases. Consequently, the sensitization trajectories found in previous studies conducted in Northern Europe may not apply in Southern European countries. ObjectiveTo identify trajectories of allergic sensitization profiles during chil...