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Valproic acid neuroprotection in the 6-OHDA model of Parkinson’s disease is pos...

Ximenes, José Christian Machado; Neves, Kelly Rose Tavares; Leal, Luzia Kalyne Almeida Moreira; Carmo, Marta Regina Santos do

Parkinson’s disease is a neurodegenerative disorder where the main hallmark is the dopaminergic neuronal loss. Besides motor symptoms, PDalso causes cognitive decline. Although current therapies focus on the restoration of dopamine levels in the striatum, prevention or disease-modifying therapies are urgently needed. Valproic acid (VA) is a wide spectrum antiepileptic drug, exerting many biochemical and physiol...

Date: 2015   |   Origin: Oasisbr
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