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Indomethacin can downregulate the levels of inflammatory mediators in the hippo...
Vieira, Michele Juliane; Perosa, Sandra Regina; Argañaraz, Gustavo Adolfo; Silva Junior, José Antônio; Cavalheiro, Esper AbrãoOBJECTIVE: Refractory status epilepticus is one of the most life-threatening neurological emergencies and is characterized by high morbidity and mortality. Additionally, the use of anti-inflammatory drugs during this period is very controversial. Thus, this study has been designed to analyze the effect of a low dose of indomethacin (a COX inhibitor) on the expression of inflammatory molecules. METHOD: The hippo...
Piperine decreases pilocarpine-induced convulsions by GABAergic mechanisms
Cruz, Giovany Michely Pinto da; Felipe, Cícero Francisco Bezerra; Scorza, Fúlvio Alexandre; Costa, Marta Aline Coelho da; Tavares, Alinne FariasPiperine, an alkaloid present in the Piper genus, was shown to have an anticonvulsant activity, evaluated by the pilocarpine-induced model, in mice. Pilocarpine (350 mg/kg, i.p.) was administered 30 min after piperine (2.5, 5, 10 and 20 mg/kg, i.p.) which significantly increased latencies to 1st convulsion and to death, and percentage of survivals. These parameters were also increased in the pilocarpine groups ...
Indomethacin can downregulate the levels of inflammatory mediators in the hippo...
Vieira, Michele Juliane; Perosa, Sandra Regina; Argaãaraz, Gustavo Adolfo; Silva Jr, José Antônio; Cavalheiro, Esper AbrãoOBJECTIVE: Refractory status epilepticus is one of the most life-threatening neurological emergencies and is characterized by high morbidity and mortality. Additionally, the use of anti-inflammatory drugs during this period is very controversial. Thus, this study has been designed to analyze the effect of a low dose of indomethacin (a COX inhibitor) on the expression of inflammatory molecules. METHOD: The hippo...
What are the similarities between stress, sudden cardiac death in Gallus gallus...
Cavalheiro, Esper Abrão
Sudden cardiac death in the young: could epilepsy be involved?
Scorza, Fulvio Alexandre; Albuquerque, Marly de; Arida, Ricardo Mario; Terra, Vera Cristina; Cavalheiro, Esper Abrão
Acute strength exercise and the involvement of small or large muscle mass on pl...
Correia, Paulo Roberto; Pansani, Aline; Machado, Felipe; Andrade, Marilia; Silva, Antonio Carlos da; Scorza, Fulvio Alexandre; Cavalheiro, Esper AbrãoOBJECTIVE: Blood neurotrophins, such as the brain-derived neurotrophic factor, are considered to be of great importance in mediating the benefits of physical exercise. In this study, the effect of acute strength exercise and the involvement of small versus large muscle mass on the levels of plasma brain-derived neurotrophic factor were evaluated in healthy individuals. METHODS: The concentric strengths of knee ...