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Management of patients at very high risk of osteoporotic fractures through sequ...

Curtis, Elizabeth M.; Reginster, Jean-Yves; Al-Daghri, Nasser; Biver, Emmanuel; Brandi, Maria Luisa; Cavalier, Etienne; Hadji, Peyman; Halbout, Philippe

Osteoporosis care has evolved markedly over the last 50 years, such that there are now an established clinical definition, validated methods of fracture risk assessment and a range of effective pharmacological agents. Currently, bone-forming (anabolic) agents, in many countries, are used in those patients who have continued to lose bone mineral density (BMD), patients with multiple subsequent fractures or those...


Multimodal multidisciplinary management of patients with moderate to severe pai...

Veronese, Nicola; Cooper, Cyrus; Bruyère, Olivier; Al-Daghri, Nasser M.; Branco, Jaime; Cavalier, Etienne; Cheleschi, Sara; Rosa, Mário Miguel

Knee osteoarthritis (OA) is one of the most common and disabling medical conditions. In the case of moderate to severe pain, a single intervention may not be sufficient to allay symptoms and improve quality of life. Examples include first-line, background therapy with symptomatic slow-acting drugs for OA (SYSADOAs) or non-steroidal anti-inflammatory drugs (NSAIDs). Therefore, the European Society for Clinical a...


Role of vitamin D supplementation in the management of musculoskeletal diseases...

Chevalley, Thierry; Brandi, Maria Luisa; Cashman, Kevin D.; Cavalier, Etienne; Harvey, Nicholas C.; Maggi, Stefania; Cooper, Cyrus; Al-Daghri, Nasser

Vitamin D is a key component for optimal growth and for calcium-phosphate homeostasis. Skin photosynthesis is the main source of vitamin D. Limited sun exposure and insufficient dietary vitamin D supply justify vitamin D supplementation in certain age groups. In older adults, recommended doses for vitamin D supplementation vary between 200 and 2000 IU/day, to achieve a goal of circulating 25-hydroxyvitamin D (c...


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