2 documents found, page 1 of 1
Silver complexes for tuberculosis treatment: a short review
Biagioni,Bruno Torquato; Cavicchioli,Maurício; Massabni,Antonio CarlosThis paper is a brief review of silver complexes that have been identified as antibacterial drugs with promising use for the treatment of tuberculosis (TB). This treatment aims to cure and discontinue the transmission of the disease. The excessive and inappropriate use of drugs has jeopardized the effectiveness of antibiotics for the TB treatment, bringing bacterial resistance to them. To achieve these objectiv...
SYNTHESIS, CHARACTERIZATION, DFT MODELING AND IN VITRO ANTIMYCOBACTERIAL ACTIVI...
Paris Junior,José Alberto; Cavicchioli,Maurício; Machado,Rachel Temperani Amaral; Pavan,Fernando Rogério; Nakahata,Douglas Hideki; Corbi,Pedro PauloIn the present work, a silver(I) complex with the antimycobacterial drug isoniazid (inh) is described. Elemental and thermogravimetric analyses confirmed a 1:1 metal:ligand ratio for the silver-isoniazid (Ag-inh) complex with molecular composition AgC6H7N3O·NO3. Infrared (IR) analysis suggests a bidentate coordination of isoniazid to silver by the nitrogen of the NH2 group and by the oxygen of the C=O group, an...