17 documents found, page 1 of 2

Toward Integrative Biomechanical Models of Osteochondral Tissues: A Multilayere...

Understanding the complex mechanical behavior of osteochondral tissues in silico is essential for improving experimental models and advancing research in joint health and degeneration. This review provides a comprehensive analysis of the constitutive models currently used to represent the different layers of the osteochondral region, from articular cartilage to subchondral bone, including intermediate regions s...

Combined use of chitosan and olfactory mucosa mesenchymal stem/stromal cells to...

Peripheral nerve injury remains a clinical challenge with severe physiological and functional consequences. Despite the existence of multiple possible therapeutic approaches, until now, there is no consensus regarding the advantages of each option or the best methodology in promoting nerve regeneration. Regenerative medicine is a promise to overcome this medical limitation, and in this work, chitosan nerve guid...

Anastomotic Leak in Colorectal Cancer Surgery: From Diagnosis to Management or ...

Anastomotic leakage (AL) after colorectal resections is a common surgical experience and the most frequent major adverse outcome. Early recognition of AL is critical to reduce mortality. We aim to evaluate the incidence, diagnostic criteria, morbidity, and mortality related with AL.

Combined Use of Chitosan and Olfactory Mucosa Mesenchymal Stem/Stromal Cells to...

Peripheral nerve injury remains a clinical challenge with severe physiological and functional consequences. Despite the existence of multiple possible therapeutic approaches, until now, there is no consensus regarding the advantages of each option or the best methodology in promoting nerve regeneration. Regenerative medicine is a promise to overcome this medical limitation, and in this work, chitosan nerve guid...

A multimodal stimulation cell culture bioreactor for tissue engineering: A nume...

The use of digital twins in tissue engineering (TE) applications is of paramount importance to reduce the number of in vitro and in vivo tests. To pursue this aim, a novel multimodal bioreactor is developed, combining 3D design with numerical stimulation. This approach will facilitate the reproducibility between studies and the platforms optimisation (physical and digital) to enhance TE. The new bioreactor was ...

Comprehensive review on full bone regeneration through 3D printing approaches

Over the last decades, the number of work accidents associated with bone fractures has increased leading to a growing concern worldwide. Currently, autografts, allografts, and xenografts are used for bone regeneration. However, their application has associated risks. Tissue engineering (TE) has brought solutions to address these problems, through the production of temporary supports, providing mechanical suppor...

Electrical Stimulation Optimization in Bioreactors for Tissue Engineering Appli...

We review here the current research status on bioreactors for tissue engineering with cell electrical stimulation. Depending on the cell types, electrical stimulation has distinct objectives: 1) being employed both to mimic and enhance endogenous electricity measured in the natural regeneration of living organisms and 2) to mimic strain working conditions for contractible tissues (for instance muscle and cardia...

Protein Nanocarriers for Targeted Drug Delivery for Cancer Therapy

This chapter describes how proteins can be used to provide effective targeted nanocarriers for drugs to target tumors. This approach offers an exciting framework for cancer therapies in the future, allowing multiple therapeutic agents and other functions to be combined in the same particle and ensuring a lower toxicity for the patient. The use of proteins provides a rich library of functional molecules to explo...

A Computer Tool for 3D Shape Recovery of Fruits

Characterizing a fruit’s mechanical behavior is an important step towards reducing economic losses due to bruising. Several 3D scanning technologies allow to obtain the external geometry of a fruit, but no easily accessible tools exist for the acquisition of the geometry of internal structures such as the core. We propose a low-cost destructive method for tomographic reconstruction of a fruit from scanned slice...

Preface of the “3rd Symposium on Integrated Computational Tools for Advanced Ma...