4 documents found, page 1 of 1
Metastatic organotropism: a brief overview
Carrolo, M; Miranda, JA; Vilhais, G; Quintela, A; Fontes e Sousa, M; Alpuim-Costa, D; Pinto, FROrganotropism has been known since 1889, yet this vital component of metastasis has predominantly stayed elusive. This mini-review gives an overview of the current understanding of the underlying mechanisms of organotropism and metastases development by focusing on the formation of the pre-metastatic niche, immune defenses against metastases, and genomic alterations associated with organotropism. The particular...
Pazopanib-Induced Cutaneous Leukocytoclastic Vasculitis: An Exclusion Diagnosis...
Costa, D; Almeida, S; Barata, P; Quintela, A; Cabral, P; Afonso, A; Silva, JIn phase II/III trials, cutaneous side effects of pazopanib were reported in less than 20% of patients, with only 1-3% being grade 3/4. We present a case of a 66-year-old man with a previous history of left nephrectomy for a stage II clear cell renal carcinoma. Approximately 18 months later, recurrent disease in the lungs, mediastinum, and left psoas and bulky abdominal/pelvic nodal metastasis were documented. ...
Pazopanib-Induced Cutaneous Leukocytoclastic Vasculitis: An Exclusion Diagnosis...
Costa, D; Almeida, S; Barata, P; Quintela, A; Cabral, P; Afonso, A; Silva, JIn phase II/III trials, cutaneous side effects of pazopanib were reported in less than 20% of patients, with only 1-3% being grade 3/4. We present a case of a 66-year-old man with a previous history of left nephrectomy for a stage II clear cell renal carcinoma. Approximately 18 months later, recurrent disease in the lungs, mediastinum, and left psoas and bulky abdominal/pelvic nodal metastasis were documented. ...
Pazopanib-Induced Cutaneous Leukocytoclastic Vasculitis: An Exclusion Diagnosis...
Alpuim Costa, D; Baptista de Almeida, S; Coelho Barata, P; Quintela, A; Cabral, P; Afonso, A; Maia Silva, JIn phase II/III trials, cutaneous side effects of pazopanib were reported in less than 20% of patients, with only 1–3% being grade 3/4. We present a case of a 66-year-old man with a previous history of left nephrectomy for a stage II clear cell renal carcinoma. Approximately 18 months later, recurrent disease in the lungs, mediastinum, and left psoas and bulky abdominal/pelvic nodal metastasis were documented. ...