2 documents found, page 1 of 1
More than just exosomes: distinct Leishmania infantum extracellular products po...
Pérez-Cabezas, Begoña; Santarém, Nuno; Cecílio, Pedro; Silva, Cátia; Silvestre, Ricardo Jorge Leal; Catita, José A. M.; Cordeiro da Silva, AnabelaThe use of secretion pathways for effector molecule delivery by microorganisms is a trademark of pathogenesis. Leishmania extracellular vesicles (EVs) were shown to have significant immunomodulatory potential. Still, they will act in conjunction with other released parasite-derived products that might modify the EVs effects. Notwithstanding, the immunomodulatory properties of these non-vesicular components and ...
Interleukin-27 early impacts Leishmania infantum infection in mice and correlat...
Pérez-Cabezas, Begoña; Cecílio, Pedro; Robalo, Ana Luísa; Silvestre, Ricardo Jorge Leal; Carrillo, Eugenia; Moreno, Javier; Martín, Juan V. SanThe complexity of Leishmania host interactions, one of the main leishmaniasis issues, is yet to be fully understood. We detected elevated IL-27 plasma levels in European patients with active visceral disease caused by Leishmania infantum, which returned to basal levels after successful treatment, suggesting this cytokine as a probable infection mediator. We further addressed this hypothesis recurring to two cla...