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Cholesterol 24S-Hydroxylase overexpression inhibits the liver X receptor (LXR) ...

Moutinho, Miguel; Nunes, Maria João; Gomes, Anita Q.; Gama, Maria João; Cedazo-Minguez, Angel; Rodrigues, C. M.; Björkhem, Ingemar; Rodrigues, Elsa

The neuronal-specific cholesterol 24S-hydroxylase (CYP46A1) is important for brain cholesterol elimination. Cyp46a1 null mice exhibit severe deficiencies in learning and hippocampal long-term potentiation, suggested to be caused by a decrease in isoprenoid intermediates of the mevalonate pathway. Conversely, transgenic mice overexpressing CYP46A1 show an improved cognitive function. These results raised the que...

Date: 2015   |   Origin: Repositório Científico do Instituto Politécnico de Lisboa
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