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Rosacea Topical Treatment and Care: From Traditional to New Drug Delivery Systems
Paiva-Santos, Ana Cláudia; Gonçalves, Tatiana; Peixoto, Diana; Pires, Patrícia C.; Velsankar, K.; Jha, Niraj Kumar; Chavda, Vivek P.Rosacea is a multifactorial chronic inflammatory dermatosis characterized by flushing, nontransient erythema, papules and pustules, telangiectasia, and phymatous alterations accompanied by itching, burning, or stinging, the pathophysiology of which is not yet fully understood. Conventional topical treatments usually show limited efficacy due to the physical barrier property of the skin that hinders skin penetra...
Antioxidant activity and validation of quantification method for lycopene extra...
Cefali, Letícia Caramori; Cazedey, Edith Cristina Laignier; Souza-Moreira, Tatiana Maria; Correa, Marcos Antônio; Salgado, Hérida Regina NunesMade available in DSpace on 2022-04-28T19:01:45Z (GMT). No. of bitstreams: 0 Previous issue date: 2015-01-01; Lycopene is a carotenoid found in tomatoes with potent antioxidant activity. The aim of the study was to obtain an extract containing lycopene from four types of tomatoes, validate a quantification method for the extracts by HPLC, and assess its antioxidant activity. Results revealed that the tomatoes a...
Effect of nanoencapsulation of blueberry (Vaccinium myrtillus): A green source ...
Franco, Julia Gomes; Cefali, Letícia Caramori; Ataide, Janaína Artem; Santini, Antonello; Souto, Eliana B.; Mazzola, Priscila GavaThe effect of nanoencapsulation on the in vitro photoprotection and antioxidant properties of blueberry (Vaccinium myrtillus) extract, before and after their dispersion into an oil-in-water emulsion and its final stability under stress conditions. Besides its skin healing activity, chitosan was chosen as wall material due to its natural origin, and possibility of obtention from shrimp residues. Chitosan/tripoly...
Flavonoid-Enriched Plant-Extract-Loaded Emulsion: A Novel Phytocosmetic Sunscre...
Cefali, Letícia Caramori; Ataide, Janaína Artem; Fernandes, Ana Rita; Sousa, Ilza Maria de Oliveira; Gonçalves, Fernanda Cristina da SilvaThe aim of this study was to develop a phytocosmetic sunscreen emulsion with antioxidant effect, containing a blend of flavonoid-enriched plant extracts. In vitro sun protection factor, antioxidant activity, skin irritation, photostability, cutaneous permeation, and retention of flavonoids were evaluated. Thermodynamically stable emulsions were obtained and tested for sensorial analysis after loading the blend ...
In vitro SPF and photostability assays of emulsion containing nanoparticles wit...
Cefali, Letícia Caramori; Ataide, Janaína Artem; Eberlin, Samara; Gonçalves, Fernanda Cristina da Silva; Fernandes, Ana Rita; Marto, JoanaThe aim of study was to determine the in vitro sun protection factor (SPF) and the photostability profile of a topical formulation composed of nanoparticles loaded with vegetable extracts and to assess its physicochemical properties. Chitosan/tripolyphosphate (TPP) nanoparticles loaded with flavonoids-enriched vegetable extracts (Ginkgo biloba L., Dimorphandra mollis Benth, Ruta graveolens, and Vitis vinifera L...
Flavonoid-enriched plant-extract-loaded emulsion: a novel phytocosmetic sunscre...
Cefali, Letícia Caramori; Ataide, Janaína Artem; Fernandes, Ana Rita; Sousa, Ilza Maria de Oliveira; Gonçalves, Fernanda Cristina da SilvaThe aim of this study was to develop a phytocosmetic sunscreen emulsion with antioxidant effect, containing a blend of flavonoid-enriched plant extracts. In vitro sun protection factor, antioxidant activity, skin irritation, photostability, cutaneous permeation, and retention of flavonoids were evaluated. Thermodynamically stable emulsions were obtained and tested for sensorial analysis after loading the blend ...
Effect of polysaccharide sources on the physicochemical properties of bromelain...
Ataide, Janaína Artem; Gérios, Eloah Favero; Cefali, Letícia Caramori; Fernandes, Ana Rita; Teixeira, Maria do Céu; Ferreira, Nuno R.Bromelain, a set of proteolytic enzymes potential pharmaceutical applications, was encapsulated in chitosan nanoparticles to enhance enzyme stability, and the effect of different chitosan sources was evaluated. Chitosan types (i.e., low molecular weight chitosan, chitosan oligosaccharide lactate, and chitosan from shrimp shells) produced nanoparticles with different physicochemical properties, however in all ca...
Evaluation of in vitro solar protection factor (SPF), antioxidant activity, and...
Cefali, Letícia Caramori; Ataide, Janaina Artem; Fernandes, Ana Rita; Sanchez-Lopez, Elena; Sousa, Ilza Maria de Oliveira; Figueiredo, Mariana CecchettoThe aim of this study was to validate a HPLC method for the assay of flavonoids in extracts obtained from natural sources, i.e., from Dirmophandra mollis Benth, Ginkgo biloba L., Ruta graveolens L., and Vitis vinífera L. The potential sun protecting effect, antioxidant activity, and cell viability of the extracts were also determined. Individual extracts (obtained from each individual species) and a mixed extra...
Development and evaluation of an emulsion containing lycopene for combating acc...
Cefali, Letícia Caramori; Souza-Moreira, Tatiana Maria; Corrêa, Marcos Antônio; Salgado, Hérida Regina Nunes; Isaac, Vera Lucia BorgesLicopeno é um carotenóide com potente atividade antioxidante encontrado em grande quantidade no tomate e usado no combate a diversas doenças como doenças cardiovasculares e diferentes tipos de cânceres, incluindo o câncer de próstata. O objetivo desse trabalho foi desenvolver uma emulsão contendo extrato de licopeno obtido do tomate salada e avaliar a citotoxicidade do extrato, a estabilidade, o comportamento r...
Design of antiseptic formulations containing extract of Plinia cauliflora
Oliveira, Lara Alexandre de; Souza-Moreira, Tatiana Maria de; Cefali, Letícia Caramori; Chiari, Bruna Galdorfini; Corrêa, Marcos AntonioThe leaves of the Brazilian species Plinia cauliflora were used to obtain active hydroalcoholic extract and fractions enabling the development of efficient antiseptic pharmaceutical formulations. A chemical composition of 70% ethanol extract, aqueous and ethyl acetate fractions was analyzed by thin-layer chromatography and for phenol content. Antimicrobial activity was tested against Staphylococcus aureus, Stap...