15 documents found, page 1 of 2
The Hermeneutic Framework: A Category for Negotiating Meaning Effects in the Wo...
Celestino, RicardoThis article explores the enunciative-discursive constitution of the hermeneutic framework in literary statements extracted from the short story collection Symetrias Dyssonantes by Luiz Brás, employing the theoretical and methodological framework of French Discourse Analysis. Based on Maingueneau (2006), the hermeneutic framework serves as a category that provides conditions for negotiating meaning effects in l...
Comprehensive Assessment of TERT mRNA Expression across a Large Cohort of Benig...
Pestana, Ana; Batista, Rui; Celestino, Ricardo; Canberk, Sule; Sobrinho-Simões, Manuel; Soares, PaulaThe presence of TERT promoter (TERTp) mutations in thyroid cancer have been associated with worse prognosis features, whereas the extent and meaning of the expression and activation of TERT in thyroid tumours is still largely unknown. We analysed frozen samples from a series of benign and malignant thyroid tumours, displaying non-aggressive features and low mutational burden in order to evaluate the presence of...
CRABP1, C1QL1 and LCN2 are biomarkers of differentiated thyroid carcinoma, and ...
Celestino, Ricardo; Nome, Torfinn; Pestana, Ana; Hoff, Andreas M.; Gonçalves, A. Pedro; Pereira, Luísa; Cavadas, Bruno; Eloy, Catarina; Bjøro, TrineBackground: The prognostic variability of thyroid carcinomas has led to the search for accurate biomarkers at the molecular level. Follicular thyroid carcinoma (FTC) is a typical example of differentiated thyroid carcinomas (DTC) in which challenges are faced in the differential diagnosis. Methods: We used high-throughput paired-end RNA sequencing technology to study four cases of FTC with different degree of c...
Literatura e mangue: análise do discurso constituinte literário em Maré Memória...
Celestino, Ricardo; Nascimento, Jarbas Vargas; Carreira, Rosangela Aparecida RibeiroEm contribuição aos estudos enunciativo-discursivos propostos, especialmente por Maingueneau, analisamos o discurso literário Maré Memória, de José Chagas, verificando como ele se situa enquanto constituinte e como opera nele a paratopia. Maré Memória foi escrito em 1973, e retrata, de maneira crítica, o abandono econômico-social do mangue e a desigualdade social em Recife. Os questionamentos expressos por José...
Innovative technologies for cancer research
Celestino, RicardoThe next-generation sequencing (NGS) and clustered regularly interspaced palindromic repeats (CRISPR)-Cas9 gene editing are innovative technologies used in genetics and molecular biology which have been revolutionizing the field of cancer research. Next-generation sequencing (NGS) is defined by modern sequencing technologies that allow to sequence millions of DNA and RNA strands much more quickly and cheaply th...
Reassessing the Evolutionary History of the 17q21 Inversion Polymorphism
Alves, Joao M; Lima, Ana C; Pais, Isa A; Amir, Nadir; Celestino, Ricardo; Piras, Giovanna; Monne, Maria; Comas, David; Heutink, Peter; Chikhi, LounèsA polymorphic inversion that lies on chromosome 17q21 comprises two major haplotype families (H1 and H2) that not only differ in orientation but also in copy-number. Although the processes driving the spread of the inversion-associated lineage (H2) in humans remain unclear, a selective advantage has been proposed for one of its subtypes. Here, we genotyped a large panel of individuals from previously overlooked...
Low frequency of TERT promoter mutations in gastrointestinal stromal tumors (GI...
Reis, R. M.; Campanella, Nathália C.; Celestino, Ricardo; Pestana, Ana; Scapulatempo-Neto, Cristovam; Oliveira, Antônio Talvane TorresSomatic mutations in the promoter region of telomerase reverse transcriptase (TERT) gene, mainly at positions c. − 124 and c. − 146 bp, are frequent in several human cancers; yet its presence in gastrointestinal stromal tumor (GIST) has not been reported to date. Herein, we searched for the presence and clinicopathological association of TERT promoter mutations in genomic DNA from 130 bona fide GISTs. We found ...
Primary squamous cell carcinoma of the thyroid diagnosed as anaplastic carcinom...
Bolfi, Fernanda [UNESP]; Domingues, Maria A. C. [UNESP]; Sobrinho-Simões, Manuel; Soares, Paula; Celestino, Ricardo; Castilho, Emanuel C. [UNESP]Made available in DSpace on 2015-12-07T15:30:31Z (GMT). No. of bitstreams: 0 Previous issue date: 2014. Added 1 bitstream(s) on 2015-12-07T15:52:58Z : No. of bitstreams: 1 PMC4175754.pdf: 2923504 bytes, checksum: 44acfab2f76a328b9de819d5069f006a (MD5); A case of primary squamous-cell carcinoma (SCC) of the thyroid which had been initially diagnosed as an anaplastic carcinoma (ATC) is described: female, 73 years...
Reassessing the Evolutionary History of the 17q21 Inversion Polymorphism
Alves, Joao M.; Lima, Ana C.; Pais, Isa A.; Amir, Nadir; Celestino, Ricardo; Piras, Giovanna; Monne, Maria; Comas, David; Heutink, Peter; Chikhi, LounèsA polymorphic inversion that lies on chromosome 17q21 comprises two major haplotype families (H1 and H2) that not only differ in orientation but also in copy-number. Although the processes driving the spread of the inversion-associated lineage (H2) in humans remain unclear, a selective advantage has been proposed for one of its subtypes. Here, we genotyped a large panel of individuals from previously overlooked...
TERT promoter mutations are a major indicator of poor outcome in differentiated...
Melo, Miguel; Gaspar Da Rocha, Adriana; Vinagre, João; Batista, Rui; Peixoto, Joana; Tavares, Catarina; Celestino, Ricardo; Almeida, AnaContext: Telomerase promoter mutations (TERT) were recently described in follicular cell-derived thyroid carcinomas (FCDTC) and seem to be more prevalent in aggressive cancers. Objectives: We aimed to evaluate the frequency of TERT promoter mutations in thyroid lesions and to investigate the prognostic significance of such mutations in a large cohort of patients with differentiated thyroid carcinomas (DTCs). De...