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Orbitofrontal sulcal and gyrus pattern in human: an anatomical study
Rodrigues,Thiago Pereira; Rodrigues,Mariana Athaniel Silva; Paz,Daniel de Araújo; Costa,Marcos Devanir Silva da; Centeno,Ricardo SilvaThe anatomical characterization of the orbitofrontal cortex in human is limited in literature instead of many functional and clinical studies involving it. Objective Anatomically define the orbitofrontal region aiming to possible neurosurgical treatments and unify the scientific nomenclature as well. Method We analyze eighty four human hemispheres using a surgical microscope. Then we chose four hemispheres and ...
Pre-surgical mood disorders associated to worse post-surgical seizure outcome i...
Araújo Filho,Gerardo Maria de; Gomes,Francinaldo Lobato; Mazetto,Lenon; Marinho,Murilo Martinez; Tavares,Igor Melo; Caboclo,Luís Otávio Sales FerreiraOBJECTIVES: This study aims at verifying the impact of pre-surgical PD on seizure outcome in patients with refractory temporal lobe epilepsy and mesial temporal sclerosis (TLE-MTS). METHODS: After previous consent, retrospective data from 115 surgically treated (corticoamygdalohyppocampectomy) TLE-MTS patients (65 females; 56.5%) were analyzed. Psychiatric evaluations were performed through DSM-IV criteria. Eng...
Temporal lobe epilepsy with mesial temporal sclerosis: hippocampal neuronal los...
Jardim,Anaclara Prada; Neves,Rafael Scarpa da Costa; Caboclo,Luís Otávio Sales Ferreira; Lancellotti,Carmen Lucia Penteado; Marinho,Murilo MartinezOBJECTIVE: To analyze retrospectively a series of patients with temporal lobe epilepsy (TLE) and mesial temporal sclerosis (MTS), and the association of patterns of hippocampal sclerosis with clinical data and surgical prognosis. METHOD: Sixty-six patients with medically refractory TLE with unilateral MTS after anterior temporal lobectomy were included. Quantitative neuropathological evaluation was performed on...
Surgical and postmortem pathology studies: contribution for the investigation o...
Caboclo,Luís Otávio Sales Ferreira; Neves,Rafael Scarpa; Jardim,Anaclara Prada; Hamad,Ana Paula Andrade; Centeno,Ricardo SilvaPathology studies in epilepsy patients bring useful information for comprehending the physiopathology of various forms of epilepsy, as well as aspects related to response to treatment and long-term prognosis. These studies are usually restricted to surgical specimens obtained from patients with refractory focal epilepsies. Therefore, most of them pertain to temporal lobe epilepsy (TLE) with mesial temporal scle...
Relationship between fluid-attenuated inversion-recovery (FLAIR) signal intensi...
Varella,Pedro Paulo Vasconcellos; Santiago,Joselita Ferreira Carvalho; Carrete Jr.,Henrique; Higa,Elisa Mieko Suemitsu; Yacubian,Elza Márcia TargasWe investigated a relationship between the FLAIR signal found in mesial temporal sclerosis (MTS) and inflammation. Twenty nine patients were selected through clinical and MRI analysis and submitted to cortico-amygdalo-hippocampectomy to seizure control. Glutamate, TNFα, IL1, nitric oxide (NO) levels and immunostaining against IL1β and CD45 was performed. Control tissues (n=10) were obtained after autopsy of pat...
Intracranial depth electrodes implantation in the era of image-guided surgery
Centeno,Ricardo Silva; Yacubian,Elza Márcia Targas; Caboclo,Luis Otávio Sales Ferreira; Carrete Júnior,Henrique; Cavalheiro,SérgioThe advent of modern image-guided surgery has revolutionized depth electrode implantation techniques. Stereoelectroencephalography (SEEG), introduced by Talairach in the 1950s, is an invasive method for three-dimensional analysis on the epileptogenic zone based on the technique of intracranial implantation of depth electrodes. The aim of this article is to discuss the principles of SEEG and their evolution from...
Employment and quality of life in mesial temporal lobe epilepsy with hippocampa...
Alonso,Neide Barreira; Azevedo,Auro Mauro; Centeno,Ricardo Silva; Guilhoto,Laura M. F. Ferreira; Caboclo,Luis Otávio Sales FerreiraPURPOSE: The aim of this study was to evaluate in patients with mesial temporal lobe epilepsy (MTLE) with hippocampal sclerosis (HS): (1) employment patterns before and three years after epilepsy surgery and their impact in Quality of Life (QOL); (2) demographic and clinical variables associated with employment. METHODS: Data from 58 patients with diagnosis of refractory MTLE with HS who had corticoamygdalo-hip...
Estereoeletroencefalografia na era da cirurgia guiada por imagem
Centeno,Ricardo Silva; Yacubian,Elza Márcia Targas; Caboclo,Luis Otávio Sales Ferreira; Carrete Júnior,Henrique; Hamad,Ana Paula AndradeINTRODUÇÃO: A estereoeletroencefalografia (E-EEG), conforme introduzida na década de 50 por Talairach, é um método invasivo de análise tridimensional da zona epilpeptogênica, baseado na técnica de implantação intracraniana de eletrodos de profundidade (EP). O advento das modernas técnicas de cirurgia guiadas por imagem revolucionaram a técnica de implantação dos EP. OBJETIVO: O objetivo deste artigo é discutir ...
Temporal pole signal abnormality on MR imaging in temporal lobe epilepsy with h...
Carrete Junior,Henrique; Abdala,Nitamar; Lin,Kátia; Caboclo,Luís Otávio; Centeno,Ricardo Silva; Sakamoto,Américo Ceiki; Szjenfeld,JacobOBJECTIVE: To determine the frequency and regional involvement of temporal pole signal abnormality (TPA) in patients with hippocampal sclerosis (HS) using fluid-attenuated inversion-recovery (FLAIR) MR imaging, and to correlate this feature with history. METHOD: Coronal FLAIR images of the temporal pole were assessed in 120 patients with HS and in 30 normal subjects, to evaluate gray-white matter demarcation. R...
Tumor fibroso solitário da meninge: relato de caso
Centeno,Ricardo Silva; Pedroso,Alessandra Augusta Gorgulho; Pereira,Emilio Marcelo; Rassi Neto,AzizO tumor fibroso solitário (TFS) é neoplasia mesenquimal rara, originalmente descrita na pleura e sendo mais recentemente também observada em vários outros sítios. Sua extensão para estruturas adjacentes não é incomum. O acometimento da meninge pelo TFS é raro, havendo relato de apenas vinte e seis casos na literatura. Apresentamos o caso de uma paciente de 25 anos, sexo feminino, com crises convulsivas tônico-c...