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Fighting Staphylococcus epidermidis Biofilm-Associated Infections: Can Iron Be ...
Oliveira, F; Rohde, H; Vilanova, M; Cerca, NStaphylococcus epidermidis is one of the most important commensal microorganisms of human skin and mucosae. However, this bacterial species is also the cause of severe infections in immunocompromised patients, specially associated with the utilization of indwelling medical devices, that often serve as a scaffold for biofilm formation. S. epidermidis strains are often multidrug resistant and its association with...
Siderophore-Mediated Iron Acquisition Plays a Critical Role in Biofilm Formatio...
Oliveira, F; Lima, T; Correia, A; Silva, AM; Soares, C; Morais, S; Weißelberg, S; Vilanova, M; Rohde, H; Cerca, NIron acquisition through siderophores, a class of small, potent iron-chelating organic molecules, is a widely spread strategy among pathogens to survive in the iron-restricted environment found in the host. Although these molecules have been implicated in the pathogenesis of several species, there is currently no comprehensive study addressing siderophore production in Staphylococcus epidermidis. Staphylococcus...
Prevalence of bacterial vaginosis in Portuguese pregnant women and vaginal colo...
Machado, D; Castro, J; Martinez-de-Oliveira, J; Nogueira-Silva, C; Cerca, NBACKGROUND: We aimed to determine the prevalence of vaginal colonization by Gardnerella vaginalis and of bacterial vaginosis (BV) in Portuguese pregnant women, and to identify risk factors for BV and G. vaginalis colonization in pregnancy. METHODS: A cross-sectional study was conducted among pregnant women aged ≥ 18 years who were attending in two public hospitals of the Northwest region of Portugal. Epidemiolo...
Poly-N-acetylglucosamine production by Staphylococcus epidermidis cells increas...
Ferreirinha, P; Pérez-Cabezas, B; Correia, A; Miyazawa, B; França, A; Carvalhais, V; Faustino, A; Cordeiro-da-Silva, A; Teixeira, L; Pier, G; Cerca, NPoly-N-acetylglucosamine (PNAG) is a major component of the Staphylococcus epidermidis biofilm extracellular matrix. However, it is not yet clear how this polysaccharide impacts the host immune response and infection-associated pathology. Faster neutrophil recruitment and bacterial clearance were observed in mice challenged intraperitoneally with S. epidermidis biofilm cells of the PNAG-producing 9142 strain th...
Biofilms7 - microbial works of art
Filipe Mergulhão; L. F. Melo; Simões M; Azevedo, NF; Azeredo, J; Pereira, MO; Henriques, M; Cerca, N; Idalina Machado