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Glucose and Lipid Dysmetabolism in a Rat Model of Prediabetes Induced by a High...

Burgeiro, Ana; Cerqueira, Manuela G.; Varela-Rodríguez, Bárbara M; Nunes, Sara; Neto, Paula; Pereira, Frederico C.; Reis, Flávio; Carvalho, Eugenia

Glucotoxicity and lipotoxicity are key features of type 2 diabetes mellitus, but their molecular nature during the early stages of the disease remains to be elucidated. We aimed to characterize glucose and lipid metabolism in insulin-target organs (liver, skeletal muscle, and white adipose tissue) in a rat model treated with a high-sucrose (HSu) diet. Two groups of 16-week-old male Wistar rats underwent a 9-wee...

Date: 2017   |   Origin: Estudo Geral - Universidade de Coimbra
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