5 documents found, page 1 of 1
Nonthermal high-pressure microalgae extracts: A new source of natural ingredien...
Garcia, Mónica P.; Regueiras, Ana; Lopes, Graciliana; Matos, Gabriela; Silva, Lucília P. da; Cerqueira, Mariana T.; Cardoso, Helena; Correia, NádiaMicroalgae are one of the most prominent sources of ingredients for the cosmetic industry not only due to their diversity but, importantly, due to the low environmental impact in production and extraction. A sustainable extraction process requires the use of effective and environmentally friendly solvents that guarantee an extract with a relevant content and in high yields. In this work, Chlorella vulgaris, Nan...
Pre-selection of fibroblasts subsets prompt prevascularization of tissue engine...
Moreira, Helena R.; Cerqueira, Mariana T.; Silva, Lucília Pereira; Pires, Joana; Jarnalo, Mariana; Horta, Ricardo; Reis, R. L.; Marques, A. P.The papillary and reticular dermis harbors phenotypically distinct fibroblasts, whose functions such as maintenance of skin's microvasculature are also distinct. Thus, we hypothesized that pre-selection of the subpopulations of fibroblasts would benefit the generation of skin tissue engineered (TE) constructs, promoting their prevascularization in vitro. We first isolated papillary and reticular fibroblasts usi...
Laminin-2 immobilized on a 3D fibrous structure impacts cortical thymic epithel...
Silva, Catarina S.; Cerqueira, Mariana T.; Reis, R. L.; Martins, Albino; Neves, N. M.The tri-dimensionality of the thymic extracellular matrix (ECM) supports the crosstalk between thymocytes and thymic epithelial cells (TECs). The thymic ECM component laminin-2 is involved in the regulation of thymocytes and their interaction with cortical TECs (cTECs). Most in vitro studies use planar surfaces to study the interaction between ECM components and thymic cells. Herein, we developed a novel biofun...
Highly tailorable gellan gum nanoparticles as a platform for the development of...
Rodrigues, Daniel Barreira; Moreira, Helena R.; Cerqueira, Mariana T.; Marques, A. P.; Castro, António G.; Reis, R. L.; Pirraco, Rogério P.Background: T cell priming has been shown to be a powerful immunotherapeutic approach for cancer treatment in terms of efcacy and relatively weak side efects. Systems that optimize the stimulation of T cells to improve therapeutic efcacy are therefore in constant demand. A way to achieve this is through artifcial antigen presenting cells that are complexes between vehicles and key molecules that target relevant...
Skin Tissue Models
Marques, A. P.; Pirraco, Rogério P.; Cerqueira, Mariana T.; Reis, R. L.Skin Tissue Models provides a translational link for biomedical researchers on the interdisciplinary approaches to skin regeneration. As the skin is the largest organ in the body, engineered substitutes have critical medical application to patients with disease and injury - from burn wounds and surgical scars, to vitiligo, psoriasis and even plastic surgery. This volume offers readers preliminary description of...