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PTS micelles for the delivery of hydrophobic methotrexate

Cerqueira, Patrícia; Noro, Jennifer Martins; Moura, Sofia; Guimarães, Diana; Silva, Carla; Cavaco-Paulo, Artur; Loureiro, Ana Isabel Sá

Polyoxyethanyl--tocopheryl sebacate (PTS) is an amphiphilic compound with self-emulsifying properties known to form micelles. In this work, we report the production of PTS micelles for the encapsulation and delivery of a hydrophobic derivative of methotrexate, MTX di-ethylated (MTX-OEt). We optimized the micelles production by testing two different techniques: auxiliary solvent and sonication. Small and homogen...

Date: 2019   |   Origin: RepositóriUM - Universidade do Minho
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