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Acute Kidney Injury after Coronary Artery Bypass Graft Surgery: The heterogenei...

Sousa, Patrícia; Moreira, Raquel; Saraiva, José; Cerqueira, Rui J.; Barros, António S.; Saraiva, Francisca A.; Leite-Moreira, Adelino

Introduction: Meta-analysis is the method to pool data from studies that report the same event in a comparable sample and, thus, summarize information from different populations. However, data extraction is limited to the information provided in the included studies. Frequently, individual patient information is not available, hence, real world data access is limited. Individual patient data (IPD) meta-analysis...


Comparing one sample’s observed survival with the expected in the general popul...

Moreira, Raquel; Saraiva, Francisca A.; Cerqueira, Rui J.; Ferreira, Ana F.; Amorim, Mário J.; Barros, António S.; Pinho, Paulo; Lourenço, André P.


EARLY AND MIDTERM OUTCOMES FOLLOWING AORTIC VALVE REPLACEMENT WITH MECHANICAL V...

Rocha, Rafael; Cerqueira, Rui J.; Saraiva, Francisca; Moreira, Sara; Barros, António S.; Almeida, Jorge; Amorim, Mário J.; Lourenço, André P.

Objectives: To compare 7-year survival and freedom from reoperation, as well as early clinical and hemodynamic outcomes, after surgical aortic valve replacement (SAVR) with mechanical or bioprosthetic valves in patients aged 50-70 years. Methods: single-center retrospective cohort study including adults aged 50-70 years who underwent SAVR in 2012 with a mechanical or bioprosthetic valve. Median follow-up was 7 ...


SAFETY AND FEASIBILITY OF CONSERVATIVE AORTIC VALVE SURGERY: SINGLE CENTER EXPE...

Cerqueira, Rui J.; Quintal, Jéni; Moreira, Soraia; Saraiva, Francisca A.; Amorim, Mário J.; Almeida, Jorge; Pinho, Paulo; Leite-Moreira, Adelino F.

Background: In selected cases, aortic valve repair (RVAo) is an alternative to prostesic aortic valve replacement. Aim: To compare mid-term survival, need of reoperation and echocardiographic findings associated with RVAo. Methods: Retrospective single-center cohort study including consecutive patients younger than 70 years-old, with non-stenotic aortic valve disease, who underwent RVAo between 2012 and 2017. A...


Neonatal Apex Resection Triggers Cardiomyocyte Proliferation, Neovascularizatio...

Sampaio-Pinto, Vasco; Rodrigues, Sílvia C.; Laundos, Tiago L.; Silva, Elsa D.; Vasques-Nóvoa, Francisco; Silva, Ana C.; Cerqueira, Rui J.

So far, opposing outcomes have been reported following neonatal apex resection in mice, questioning the validity of this injury model to investigate regenerative mechanisms. We performed a systematic evaluation, up to 180 days after surgery, of the pathophysiological events activated upon apex resection. In response to cardiac injury, we observed increased cardiomyocyte proliferation in remote and apex regions,...


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