Made available in DSpace on 2018-12-11T17:04:51Z (GMT). No. of bitstreams: 0 Previous issue date: 2016-11-01; Aldosterone plays a pivotal role in the pathophysiology of systolic heart failure. However, whether early aldosterone antagonism improves cardiac remodeling during persistent pressure overload is unsettled. We evaluated the effects of aldosterone antagonist spironolactone on cardiac remodeling in rats w...