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A computational approach using bioinformatics to screening drug targets for Lei...

Leite, João Paulo Viana; Chávez-Fumagalli, Miguel Angel; Schneider, Mônica Santos; Lage, Daniela Pagliara; Tavares, Grasiele de Sousa Vieira

The development of new therapeutic strategies to treat patients for leishmaniasis has become a priority. The antileishmanial activity of the strychnobiflavone flavonoid was recently demonstrated against Leishmania amazonensis and Leishmania infantum amastigotes and promastigotes. The biological effect of this molecule was identified due to its capacity to interfere in the parasite mitochondrial membrane; howeve...

Date: 2019   |   Origin: Oasisbr
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