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Loss of antiphospholipid antibody positivity decreases the risk of recurrent th...
Gaspar, Pedro; Cruz-Machado, Ana Rita; Abrantes, Ana Mafalda; Costa, Filipa; Parreira, Inês; Lopes, Ana Rita; Costa-Silva, Ryan; Chícharo, Ana TeodósioOBJECTIVE: To establish the predictive value of antiphospholipid antibody (aPL) negativization on recurrent thrombosis in thrombotic antiphospholipid syndrome (APS). METHODS: Retrospective cohort study including all consecutive adult patients with APS followed at Hospital de Santa Maria, Lisbon, Portugal, up to December 2024. At diagnosis, all patients were positive for solid-phase aPL. Then, patients were cate...
Pregnancy outcomes in systemic sclerosis: experience of a rheumatology-obstetri...
Chícharo, Ana Teodósio; Lopes, Ana Rita; Barreira, Sofia; Martins, Patrícia; Machado, Ana Rita Cruz; Pinto, Luísa; Capela, SusanaSystemic sclerosis (SSc) is a rare multisystemic connective tissue disease (CTD). It is mainly characterized by progressive fibrosis and non-inflammatory vasculopathy. Women diagnosed with SSc seem to be at increased risk of developing adverse pregnancy outcomes (APO), but maternal and perinatal outcomes remain poorly understood in these patients, with no data yet available from Portuguese centers.
Dual challenge inside the womb: a case report of concomitant fetal atrio-ventri...
Chícharo, Ana Teodósio; Rebelo, Mónica; Lopes, Ana Rita; Saavedra, Maria João; Paramés, Maria Filipa; Araújo, Ana Rita; Machado, Ana Rita CruzFetal autoimmune atrioventricular block (AVB) is a rare but potentially life-threatening condition. It results from the passage of maternal anti-SSA/Ro or Anti SSB/La auto-antibodies into the fetal circulation, leading to inflammation and fibrosis of the AV node and often to irreversible damage. Besides AVB, these antibodies can also cause cardiomyopathies, but there is no evidence linking them to tachyarrhythm...
Jaccoud’s arthropathy in osteogenesis imperfecta
Martins, Frederico Rajão; Rocha, Margarida Lucas; Chícharo, Ana Teodósio; Teixeira, Vítor SilvestreType I osteogenesis imperfecta is a genetic disease associated with mutations in the pro-alpha1 chains of type 1 collagen encoder gene COL1A1. It has an autosomal dominant pattern of inheritance, and leads to reduction in the amount of structurally normal collagen and subsequently, disorders of the extracellular membrane of skin, tendons and bone.
Maternal and perinatal outcomes in pregnant women with rheumatic diseases treat...
Chícharo, Ana Teodósio; Lopes, Ana R.; Barreira, Sofia; Pinto, Luísa; Machado, Ana R. Cruz; Capela, SusanaNo safety or efficacy issues arose from using biosimilar TNFi during conception or pregnancy.
Predictors of cardiac involvement in idiopathic inflammatory myopathies
Bandeira, Matilde; Dourado, Eduardo; Melo, Ana Teresa; Martins, Patrícia; Fraga, Vanessa; Ferraro, José Luís; Saraiva, André; Sousa, MarleneObjectives: Idiopathic inflammatory myopathies (IIM) are a group of rare disorders that can affect the heart. This work aimed to find predictors of cardiac involvement in IIM. Methods: Multicenter, open cohort study, including patients registered in the IIM module of the Rheumatic Diseases Portuguese Register (Reuma.pt/Myositis) until January 2022. Patients without cardiac involvement information were excluded....