100 documents found, page 1 of 10
Deep Eutectic Systems: A Game Changer for Marine Bioactives Recovery
Amador, Sandro; Martins, Alice; Matias, Margarida; Pedrosa, Rui; Pinteus, SuseteThe extraction of bioactive compounds from marine natural products has gained increasing attention due to their diverse applications, such as in pharmaceuticals, nutraceuticals, and cosmetics. Yet, low extraction yields and toxicity associated with common solvents are a major bottleneck. Deep eutectic solvents (DESs) and natural deep eutectic solvents (NADESs) have emerged as promising green alternatives to con...
Chemical Characterization and Bio-Screening of Neuroprotective Potential of Bra...
dos Santos, Thalisia Cunha; Obando, Johana Marcela Concha; Silva, Joana; Santos, Ana Luíza Vidal Pimentel; Martins, Roberto Carlos CamposBrazilian native seaweed Canistrocarpus cervicornis (Ochrophyta, Dictyotaceae) is recognized for its chemodiversity, particularly cyclic diterpenes and polysaccharides, yet its relevance to neurological disorders remains unexplored. This study evaluated the neuroprotective potential of a hydroethanolic extract (ECCH), its polar fraction (CCFPol), a dichloromethane extract (ECCD), and eight derived fractions (CC...
Sulfated polysaccharides from macroalgae: A simple roadmap for chemical charact...
Martins, Alice; Alves, Celso; Silva, Joana; Pinteus, Susete; Gaspar, Helena; Pedrosa, RuiThe marine environment presents itself as a treasure chest, full of a vast diversity of organisms yet to be explored. Among these organisms, macroalgae stand out as a major source of natural products due to their nature as primary producers and relevance in the sustainability of marine ecosystems. Sulfated polysaccharides (SPs) are a group of polymers biosynthesized by macroalgae, making up part of their cell w...
New insights into the dermocosmetic potential of the red seaweed Gelidium corneum
Matias, Margarida; Martins, Alice; Alves, Celso; Silva, Joana; Pinteus, Susete; Fitas, Manuel; Pinto, Pedro; Marto, Joana; Ribeiro, HelenaThis work addresses the potential of the red seaweed Gelidium corneum as a source of bioactive ingredients for skin health and wellness in response to the growing awareness regarding the significance of sustainable strategies in developing new nature-based dermocosmetic products. Hydroalcoholic extracts from the dried biomass were subjected to sequential liquid–liquid partitions, affording five different fracti...
Lanthanide-based organic salts: Synthesis, characterization, and cytotoxicity s...
Forte, Andreia; Gago, Sandra; Alves, Celso; Silva, Joana; Pedrosa, Rui; Laia, César A.T.; Marrucho, Isabel M.; Branco, Luis C.The formulation of magnetic ionic liquids (MILs) or organic salts based on lanthanides as anions has been explored. In this work, a set of choline-family-based salts, and two other, different cation families, were combined with Gadolinium(III) and Terbium(III) anions. Synthetic methodologies were previously optimized, and all organic salts were obtained as solids with melting temperatures higher than 100 °C. Th...
Valorisation of Sargassum muticum through the extraction of phenolic compounds ...
Jesus, Bárbara C.; Sáenz de Miera, Blanca; Santiago, Rubén; Martins, Alice; Pedrosa, Rui; Gonzalez-Miquel, Maria; Marrucho, Isabel M.Seaweeds are naturally abundant and spread all over the globe. They have several biologically active secondary metabolites of great interest. In this work, Sargassum muticum was the algae employed as biomass and the aim was to extract phenolic compounds (PCs) using eutectic solvents (ESs). Several betaine-based, proline-based, and choline-based ESs were tested for the extraction of PCs. All extracts were evalua...
Valorization of the red seaweed Gracilaria gracilis through a biorefinery approach
Martins, Alice; Pinto, Filipa R.; Barroso, Sónia; Pereira, Tatiana; Mouga, Teresa; Afonso, Clélia; Freitas, Marta V.; Pinteus, Susete; Pedrosa, RuiThe interest in seaweeds as an abundant feedstock to obtain valuable and multitarget bioactive ingredients is continuously growing. In this work, we explore the potential of Gracilaria gracilis, an edible red seaweed cultivated worldwide for its commercial interest as a source of agar and other ingredients for cosmetic, pharmacological, food, and feed applications. G. gracilis growth conditions were optimized t...
Disclosing the antitumour potential of the marine bromoditerpene sphaerococceno...
Alves, Celso; Silva, Joana; Afonso, Marta B; Guedes, Romina A.; Guedes, Rita C.; Alvariño, Rebeca; Pinteus, Susete; Gaspar, Helena; Goettert, Márcia I.Nature has revealed to be a key source of innovative anticancer drugs. This study evaluated the antitumour potential of the marine bromoditerpene sphaerococcenol A on different cancer cellular models. Dose-response analyses (0.1-100 µM; 24 h) were accomplished in eight different tumour cell lines (A549, CACO-2, HCT-15, MCF-7, NCI-H226, PC-3, SH-SY5Y, SK-MEL-28). Deeper studies were conducted on MFC-7 cells, nam...
Preservation of fresh-cut Rocha Pear using Codium tomentosum extract
Augusto, Ana; Miranda, Andreia; Crespo, Daniel; Campos, Maria J.; Raimundo, Délio; Pedrosa, Rui; Mitchell, Geoffrey; Niranjan, KeshavanRocha is a Portuguese pear cultivar with high economic importance in the Portuguese Western Region. Degradative processes following its manipulation can quickly lead to product rejection, especially when sold as a freshcut product. The efficacy of a marine-based edible coating to inhibit superficial browning development in freshcut Rocha pear slices was investigated over a storage period of 15 days. The aqueous...
Disclosing the antitumour potential of the marine bromoditerpene sphaerococceno...
Alves, Celso; Silva, Joana; Afonso, Marta B.; Guedes, Romina A.; Guedes, Rita C.; Alvariño, Rebeca; Pinteus, Susete; Gaspar, Helena; Goettert, Marcia I.Nature has revealed to be a key source of innovative anticancer drugs. This study evaluated the antitumour potential of the marine bromoditerpene sphaerococcenol A on different cancer cellular models. Dose-response analyses (0.1–100 μM; 24 h) were accomplished in eight different tumour cell lines (A549, CACO-2, HCT-15, MCF-7, NCI-H226, PC-3, SH-SY5Y, SK-MEL-28). Deeper studies were conducted on MFC-7 cells, nam...