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Spatiotemporal control of mitotic exit during anaphase by an aurora B-Cdk1 cros...
Afonso, O; Castellani, CM; Cheeseman, LP; Ferreira, JG; Orr, B; Ferreira, LT; Chambers, JJ; Morais-de-Sá, E; Maresca, TJ; Maiato, HAccording to the prevailing ‘clock’ model, chromosome decondensation and nuclear envelope reformation when cells exit mitosis are byproducts of Cdk1 inactivation at the metaphase-anaphase transition, controlled by the spindle assembly checkpoint. However, mitotic exit was recently shown to be a function of chromosome separation during anaphase, assisted by a midzone Aurora B phosphorylation gradient-the ‘ruler’...
Date: 2019
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Origin: Repositório Aberto da Universidade do Porto