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American Academy of Periodontology best evidence consensus statement on the use...

Avila-Ortiz, Gustavo; Ambruster, Jeanne; Barootchi, Shayan; Chambrone, Leandro; Chen, Chia-Yu; Dixon, Douglas R.; Geisinger, Maria L.

A biologic is a therapeutic agent with biological activity that is administered to achieve an enhanced regenerative or reparative effect. The use of biologics has progressively become a core component of contemporary periodontal practice. However, some questions remain about their safety, indications, and effectiveness in specific clinical scenarios. Given their availability for routine clinical use and the exi...


An umbrella review of the evidence linking oral health and systemic noncommunic...

Botelho, João; Mascarenhas, Paulo; Viana, João; Proença, Luís; Orlandi, Marco; Leira, Yago; Chambrone, Leandro; Mendes, José João; Machado, Vanessa

Oral diseases are highly prevalent worldwide. Recent studies have been supporting a potential bidirectional association of oral diseases with systemic noncommunicable diseases (NCDs). Available evidence supports that people with NCDs have a greater prevalence of oral diseases particularly those with limited ability of oral self-care. Regarding the reverse relationship, the lines of evidence pointing out NCDs as...


Antibiotic therapy for the prevention of osteoradionecrosis following tooth ext...

Palma, Luiz Felipe; Marcucci, Marcelo; Remondes, Cíntia Maria; Chambrone, Leandro

Introduction: One of the most important complications of radiotherapy (RT) for head-and-neck cancer (HNC) is osteoradionecrosis (ORN) of the jaws, which mostly arises from tooth extractions. The ORN treatment still represents a great challenge; therefore, the prevention is of paramount importance. Thus, the present study aimed to evaluate retrospectively a perioperative systemic antibiotic therapy protocol for ...


Periodontal health, nutrition and anthropometry in professional footballers : a...

Botelho, João; Vicente, Filipa; Dias, Laura; Júdice, André; Pereira, Paula; Proença, Luís; Machado, Vanessa; Chambrone, Leandro; Mendes, José João

Poor oral health in elite sport is a pressing issue, however little is known about the periodontal status of professional footballers. The aim of this study was to examine the prevalence of periodontitis in a group of professional footballers and its association with nutritional parameters and self-report non-traumatic injuries. Additionally, we assessed its association with anthropometric, dietary inflammatory...


Periodontitis impact in interleukin-6 serum levels in solid organ transplanted ...

Machado, Vanessa; Botelho, João; Lopes, Joana; Patrão, Mariana; Alves, Ricardo; Chambrone, Leandro; Alcoforado, Gil; Mendes, José João

This systematic review aimed to investigate the influence of periodontitis on post-transplant IL-6 serum levels of solid organ transplanted patients as compared to healthy subjects. Four databases (PubMed, Scholar, EMBASE, and CENTRAL) were searched up to February 2020 (PROSPERO CRD42018107817). Case-control and cohort studies on the association of IL-6 serum levels with a periodontal status of patients after s...



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