2 documents found, page 1 of 1
Roadmap on nanomedicine for the central nervous system
Ciofani, Gianni; Campisi, Marco; Mattu, Clara; Kamm, Roger D.; Chiono, Valeria; Raynold, Aji Alex Moothedathu; Freitas, João S.; Redolfi Riva, EugenioIn recent years, a great deal of effort has been undertaken with regards to treatment of pathologies at the level of the central nervous system (CNS). Here, the presence of the blood-brain barrier acts as an obstacle to the delivery of potentially effective drugs and makes accessibility to, and treatment of, the CNS one of the most significant challenges in medicine. In this Roadmap article, we present the stat...
Transcription- and phosphorylation-dependent control of a functional interplay ...
El Manaa, Wejdane; Duplan, Eric; Goiran, Thomas; Lauritzen, Inger; Vaillant Beuchot, Loan; Lacas-Gervais, Sandra; Morais, Vanessa A.; You, Han; Qi, LingParkinson disease (PD)-affected brains show consistent endoplasmic reticulum (ER) stress and mitophagic dysfunctions. The mechanisms underlying these perturbations and how they are directly linked remain a matter of questions. XBP1 is a transcription factor activated upon ER stress after unconventional splicing by the nuclease ERN1/IREα thereby yielding XBP1s, whereas PINK1 is a kinase considered as the sensor ...