3 documents found, page 1 of 1
Umbilical-Cord-Derived Mesenchymal Stromal Cells Modulate 26 Out of 41 T Cell S...
Laranjeira, Paula; Dos Santos, Francisco; Salvador, Maria João; Simões, Irina N.; Cardoso, Carla M. P.; Silva, Bárbara M.; Henriques-Antunes, HelenaSystemic sclerosis (SSc) is an immune-mediated disease wherein T cells are particularly implicated, presenting a poor prognosis and limited therapeutic options. Thus, mesenchymal-stem/stromal-cell (MSC)-based therapies can be of great benefit to SSc patients given their immunomodulatory, anti-fibrotic, and pro-angiogenic potential, which is associated with low toxicity. In this study, peripheral blood mononucle...
Soft culture substrates favor stem-like cellular phenotype and facilitate repro...
Gerardo, Heloísa; Lima, Ana; Carvalho, João; Ramos, João R. D.; Couceiro, Sofia; Travasso, Rui D.; Neves, Ricardo Pires das; Grãos, MárioBiophysical cues influence many aspects of cell behavior. Stiffness of the extracellular matrix is probed by cells and transduced into biochemical signals through mechanotransduction protein networks, strongly influencing stem cell behavior. Cellular stemness is intimately related with mechanical properties of the cell, like intracellular contractility and stiffness, which in turn are influenced by the microenv...
The multigenic structure of the MHC locus contributes to positive selection eff...
Monteiro, Miguel Caetano; Couceiro, Sofia; Penha-Gonçalves, CarlosThe study of T cell positive selection in the thymus has long been focused on the specificity of the MHC-TCR interactions, making use of genetically manipulated mice that display TCR specificities or selecting peptides of limited diversity. However, little is known on the role of the MHC molecules irrespective of the peptide specificity and the implications of MHC multigenic structure in thymic positive selecti...