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miR-139-5p protects septic mice with acute lung injury by inhibiting Toll-like ...

OBJECTIVES: To investigate the role of miR-139-5p and the TLR4/MyD88/NF-kB signaling pathway in acute lung injury in septic mice. METHOD: A total of 140 healthy male SPF C57BL/6 mice were divided into seven groups, i.e., Normal, Control, NC, miR-139-5p mimic, miR-139-5p inhibitor, TAK-242, and miR-139-5p inhibitor+TAK-242 groups. The levels of miR-139-5p, proteins related to the TLR4/MyD88/NF-kB signaling pathw...