4 documents found, page 1 of 1
Pluronic® F127 Hydrogel Containing Silver Nanoparticles in Skin Burn Regenerati...
Francisco, Pedro; Neves Amaral, Mariana; Neves, Afonso; Ferreira-Gonçalves, Tânia; Viana, Ana S.; Catarino, José; Faísca, Pedro; Simões, SandraPresently, skin burns are considered one of the main public health problems and lack therapeutic options. In recent years, silver nanoparticles (AgNPs) have been widely studied, playing an increasingly important role in wound healing due to their antibacterial activity. This work is focused on the production and characterization of AgNPs loaded in a Pluronic® F127 hydrogel, as well as assessing its antimicrobia...
Gold-Based Nanoplataform for the Treatment of Anaplastic Thyroid Carcinoma: A S...
Amaral, Mariana; Charmier, Adília J.; Afonso, Ricardo A.; Catarino, José; Faísca, Pedro; Carvalho, Lina; Ascensão, Lia; Coelho, João M. P.Anaplastic thyroid carcinoma (ATC) is a very rare subtype of thyroid carcinoma and one of the most lethal malignancies. Poor prognosis is mainly associated with its undifferentiated nature, inoperability, and failing to respond to the typically used therapies for thyroid cancer. Photothermal Therapy (PTT) entails using light to increase tissues’ temperature, leading to hyperthermia-mediated cell death. Tumours ...
How Can Biomolecules Improve Mucoadhesion of Oral Insulin? A Comprehensive Insi...
Amaral, Mariana; Martins, Ana Sofia; Catarino, José; Faísca, Pedro; Kumar, Pradeep; Pinto, João F.; Pinto, Rui; Correia, Isabel; Ascensão, LiaCurrently, insulin can only be administered through the subcutaneous route. Due to the flaws associated with this route, it is of interest to orally deliver this drug. However, insulin delivered orally has several barriers to overcome as it is degraded by the stomach's low pH, enzymatic content, and poor absorption in the gastrointestinal tract. Polymers with marine source like chitosan are commonly used in nan...
How can biomolecules improve mucoadhesion of oral insulin? A comprehensive insi...
Amaral, Mariana; Martins, Ana Sofia; Catarino, José; Faísca, Pedro; Kumar, Pradeep; Pinto, João F.; Pinto, Rui; Correia, Isabel; Ascensão, LiaCurrently, insulin can only be administered through the subcutaneous route. Due to the flaws associated with this route, it is of interest to orally deliver this drug. However, insulin delivered orally has several barriers to overcome as it is degraded by the stomach’s low pH, enzymatic content, and poor absorption in the gastrointestinal tract. Polymers with marine source like chitosan are commonly used in nan...