16 documents found, page 1 of 2
Inhibitors of calpain activation (PD150606 and E-64) and renal ischemia-reperfu...
Chatterjee, PK; Todorovic, Z; Sivarajah, A; Mota-Filipe, H; Brown, PAJ; Stewart, KN; Mazzon, E; Cuzzocrea, S; Thiemermann, CCalpain activation has been implicated in the development of ischemia-reperfusion (I-R) injury. Here we investigate the effects of two inhibitors of calpain activity, PD150606 and E-64, on the renal dysfunction and injury caused by I-R of rat kidneys in vivo. Male Wistar rats were administered PD150606 or E-64 (3 mg/kg i.p.) or vehicle (10%, v/v, DMSO) 30 min prior to I-R. Rats were subjected to bilateral renal...
Differential effects of caspase inhibitors on the renal dysfunction and injury ...
Chatterjee, PK; Todorovic, Z; Sivarajah, A; Mota-Filipe, H; Brown, PAJ; Stewart, KN; Cuzzocrea, S; Thiemermann, CCaspase activation has been implicated in the development of ischemia-reperfusion injury. Here, we investigate the effects of different caspase inhibitors on the renal dysfunction and injury caused by ischemia-reperfusion of the rat kidney. Bilateral clamping of renal pedicles (45 min) followed by reperfusion (6 h) caused significant renal dysfunction and marked renal injury. Caspase-1 inhibitor II (N-acetyl-L-...
EUK-134 reduces renal dysfunction and injury caused by oxidative and nitrosativ...
Chatterjee, PK; Patel, NSA; Kvale, EO; Brown, PAJ; Stewart, KN; Mota-Filipe, H; Sharpe, MA; Di Paola, R; Cuzzocrea, S; Thiemermann, CBackground/Aims: Oxidative and nitrosative stress plays important roles in the pathogenesis of renal ischemia/ reperfusion (I/R) injury. Here we investigate the effect of EUK-134, a synthetic superoxide dismutase and catalase mimetic, (i) on renal dysfunction and injury caused by I/R in vivo and (ii) on proximal tubular cell (PTC) injury and death caused by oxidative and nitrosative stress. Methods: Rats, subje...
The cyclopentenone prostaglandin 15-deoxy-Delta(12,14)-prostaglandin J(2) ameli...
Chatterjee, PK; Patel, NSA; Cuzzocrea, S; Brown, PAJ; Stewart, KN; Mota-Filipe, H; Britti, D; Eberhardt, W; Pfeilschifter, J; Thiemermann, CObjective: Here we investigate the effects of the endogenous prostaglandin D-2 metabolite 15-deoxy-Delta(12,14)-prostaglandin J(2), on the renal dysfunction and injury caused by ischemia/reperfusion of the kidney. Methods: Male Wistar rats, subjected to bilateral renal ischemia for 45 min followed by reperfusion for up to 48 h, were administered 15-deoxy-Delta(12,14)-prostaglandin J(2) (1 mg/kg, intravenously) ...
5-Aminoisoquinolinone reduces renal injury and dysfunction caused by experiment...
Chatterjee, PK; Chatterjee, BE; Pedersen, H; Sivarajah, A; McDonald, MC; Mota-Filipe, H; Brown, PAJ; Stewart, KN; Cuzzocrea, S; Threadgill, MDBackground. Poly (ADP-ribose) polymerase (PARP), a nuclear enzyme activated by strand breaks in DNA, plays an important role in the development of ischemia/reperfusion (I/R) injury. The aim of this study was to investigate the effects of a water-soluble and potent PARP inhibitor, 5-aminoisoquinolinone (5-AIQ), on the renal injury and dysfunction caused by oxidative stress of the rat kidney in vitro and in vivo....
The tyrosine kinase inhibitor tyrphostin AG126 reduces renal ischemia/reperfusi...
Chatterjee, PK; Patel, NSA; Kvale, EO; Brown, PAJ; Stewart, KN; Britti, D; Cuzzocrea, S; Mota-Filipe, H; Thiemermann, CBackground. We investigate the effects of tyrphostin AG126, an inhibitor of tyrosine kinase activity, on the renal dysfunction and injury caused by ischemia/reperfusion (I/R) of the kidney. Methods. Tyrphostin AG126 (5 mg/kg intraperitoneally) was administered to male Wistar rats 30 minutes prior to bilateral renal ischemia for 45 minutes followed by reperfusion for up to 48 hours. Biochemical markers of renal ...
Agonists of peroxisome-proliferator activated receptor-gamma reduce renal ische...
Sivarajah, A; Chatterjee, PK; Patel, NSA; Todorovic, Z; Hattori, Y; Brown, PAJ; Stewart, KN; Mota-Filipe, H; Cuzzocrea, S; Thiemermann, CBackground/Aims: Recent evidence indicates that peroxisome-proliferator activated receptor (PPAR) agonists protect against ischemia/reperfusion (I/R) injury. Here we investigate the effects of the PPAR-gamma agonists, rosiglitazone and ciglitazone, on the renal dysfunction and injury caused by I/R of the rat kidney in vivo. Methods: Rosiglitazone or ciglitazone were administered to male Wistar rats prior to and...
High density lipoprotein (HDL) reduces renal ischemia/reperfusion injury
Thiemermann, C; Patel, NSA; Kvale, EO; Cockerill, GW; Brown, PAJ; Stewart, KN; Cuzzocrea, S; Britti, D; Mota-Filipe, H; Chatterjee, PKHigh-density lipoproteins (HDL) have been shown to reduce organ injury and mortality in animal models of shock via modulation of the expression of adhesion molecules and pro-inflammatory enzymes. As renal inflammation plays an important role in the development of ischemia/reperfusion (I/R) injury of the kidney, the aim of this study was to investigate the ability of HDL to alleviate renal dysfunction and injury...
GW274150, a potent and highly selective inhibitor of iNOS, reduces experimental...
Chatterjee, PK; Patel, NSA; Sivarajah, A; Kvale, EO; Dugo, L; Cuzzocrea, S; Brown, PAJ; Stewart, KN; Mota-Filipe, H; Britti, D; Yaqoob, MMBackground. Generation of nitric oxide (NO) by inducible nitric oxide synthase (iNOS) may contribute to renal ischemia/reperfusion (I/R) injury. The aim of this study was to investigate the effects of GW274150, a novel, highly selective, potent and long-acting inhibitor of iNOS activity in rat and mouse models of renal I/R. Methods. Rats were administered GW274150 (5 mg/kg intravenous bolus administered 30 minu...
Inhibition of inducible nitric oxide synthase reduces renal ischemia/reperfusio...
Chatterjee, PK; Patel, NSA; Kvale, EO; Cuzzocrea, S; Brown, PAJ; Stewart, KN; Mota-Filipe, H; Thiemermann, CBackground. Nitric oxide (NO), produced via inducible nitric oxide synthase (iNOS), is implicated in the pathophysiology of renal ischemia/reperfusion (I/R) injury. The aim of this study was to investigate the effects of the iNOS inhibitors L-N-6-(1-iminoethyl)lysine (L-NIL) and aminoethyl-isothiourea (AE-ITU) on (a) renal dysfunction and injury mediated by bilateral I/R of rat kidneys in vivo and (b) cytokine-...