36 documents found, page 1 of 4
Physicochemical and biopharmaceutical aspects influencing skin permeation and r...
Souto, Eliana; Fangueiro, Joana F.; Fernandes, Ana R.; Cano, Amanda; Sanchez-Lopez, Elena; Garcia, Maria L.; Severino, Patrícia; Paganelli, Maria O.The skin is a complex and multifunctional organ, in which the static versus dynamic balance is responsible for its constant adaptation to variations in the external environment that is continuously exposed. One of the most important functions of the skin is its ability to act as a protective barrier, against the entry of foreign substances and against the excessive loss of endogenous material. Human skin impose...
Physicochemical and biopharmaceutical aspects influencing skin permeation and r...
Souto, Eliana B.; Fangueiro, Joana F.; Fernandes, Ana R.; Cano, Amanda; Sanchez-Lopez, Elena; Garcia, Maria L.; Severino, Patrícia; Paganelli, Maria O.The skin is a complex and multifunctional organ, in which the static versus dynamic balance is responsible for its constant adaptation to variations in the external environment that is continuously exposed. One of the most important functions of the skin is its ability to act as a protective barrier, against the entry of foreign substances and against the excessive loss of endogenous material. Human skin impose...
Cashew Gum (Anacardium occidentale) as a Potential Source for the Production of...
Loureiro, Kahynna C.; Jäger, Alessandro; Pavlova, Ewa; Lima-Verde, Isabel B.; Štěpánek, Petr; Sangenito, Leandro S.; Santos, André L. S.Every year, more than thirty thousand tons of Cashew gum (Anacardium occidentale, family: Anacardiaceae) are produced in Brazil; however, only a small amount is used for different applications in foodstuff and in pharmaceutical industries. As a raw material for the production of drug delivery systems, cashew gum is still regarded as an innovative compound worth to be exploited. In this work, cashew gum was extr...
Production of bacterial cellulose nanocrystals via enzymatic hydrolysis and eva...
Soeiro, Victória S.; Tundisi, Louise L.; Novaes, Letícia C. L.; Mazzola, Priscila G.; Aranha, Norberto; Grotto, Denise; Júnior, José M. O.This study aimed to obtain the bacterial cellulose nanocrystals (CNC) by enzymatic hydrolysis and verify the CNC application as coating material in alginate particles. Therefore, the production of CNC was carried out through two enzymatic hydrolysis methods involving a time period of 48 and 72 h. 0.35 mg of dry mass of cellulose was produced approximately 1.6 × 1011 CNC/mL. The CNC obtained by enzymatic hydroly...
Overcoming multi-resistant leishmania treatment by nanoencapsulation of potent ...
Oliveira, Simone S. C.; Ferreira, Carine S.; Branquinha, Marta H.; Santos, André L. S.; Chaud, Marco V.; Jain, Sona; Cardoso, Juliana C.Leishmaniasis corresponds to a group of neglected tropical diseases caused by flagellated protozoa belonging to the Leishmania genus. This widely spread illness is found in over 90 countries in the tropic and sub-tropic regions and also in southern Europe. As parasites exclusively infect the highly phagocytic cells (macrophages), this aspect can be exploited for targeted delivery making use of nanoparticles. Dr...
Curcumin encapsulation in nanostructures for cancer therapy: a 10-year overview
D'Angelo, Natália A.; Noronha, Mariana A.; Kurnik, Isabelle S.; Câmara, Mayra C. C.; Vieira, Jorge; Abrunhosa, Luís; Martins, Joana T.Curcumin (CUR) is a phenolic compound present in some herbs, including Curcuma longa Linn. (turmeric rhizome), with a high bioactive capacity and characteristic yellow color. It is mainly used as a spice, although it has been found that CUR has interesting pharmaceutical properties, acting as a natural antioxidant, anti-inflammatory, antimicrobial, and antitumoral agent. Nonetheless, CUR is a hydrophobic compou...
Applications of natural, semi-synthetic, and synthetic polymers in cosmetic for...
Alves, Thais F. R.; Morsink, Margreet; Batain, Fernando; Chaud, Marco V.; Almeida, Taline; Fernandes, Dayane A.; da Silva, Classius F.; Souto, Eliana B.Cosmetics composed of synthetic and/or semi-synthetic polymers, associated or not with natural polymers, exhibit a dashing design, with thermal and chemo-sensitive properties. Cosmetic polymers are also used for the preparation of nanoparticles for the delivery of, e.g., fragrances, with the purpose to modify their release profile and also reducing the risk of evaporation. Besides, other cosmetically active nut...
Bilayer mucoadhesive buccal film for mucosal ulcers treatment: development, cha...
Alves, Thais F. R.; Rios, Alesssandra C.; da Silva Pontes, Katiusca; Portella, Decio L.; Aranha, Norberto; Severino, Patricia; Souto, Eliana B.The formation of mucosal ulcers is an end result of epithelial damage, and it occurs due to some specific causes, such as trauma, aphthous stomatitis, lichen planus and lichenoid reactions, cytotoxic effects of chemotherapy and radiation, and drug-induced hypersensitivity reactions and malignant settings. This study focused on films for target drug delivery with respect to the treatment of the diseases of the o...
β-cyclodextrin/isopentyl caffeate inclusion complex: synthesis, characterizatio...
Marques, Carine S. F.; Barreto, Nathalia S.; Oliveira, Simone S. C. de; Santos, André L. S.; Branquinha, Marta H.; Sousa, Damião P. de; Castro, MayaraIsopentyl caffeate (ICaf) is a bioactive ester widely distributed in nature. Our patented work has shown promising results of this molecule against Leishmania. However, ICaf shows poor solubility, which limits its usage in clinical settings. In this work, we have proposed the development of an inclusion complex of ICaf in -cyclodextrin (-CD), with the aim to improve the drug solubility, and thus, its bioavailab...
Nanotoxicology and Nanosafety: Safety-by-Design and Testing at a Glance
Zielinska, Aleksandra; Costa, Beatriz; Ferreira, Maria V.; Miguéis, Diogo; Louros, Jéssica M. S.; Durazzo, Alessandra; Lucarini, Massimo; Eder, PiotrThis review offers a systematic discussion about nanotoxicology and nanosafety associated with nanomaterials during manufacture and further biomedical applications. A detailed introduction on nanomaterials and their most frequently uses, followed by the critical risk aspects related to regulatory uses and commercialization, is provided. Moreover, the impact of nanotoxicology in research over the last decades is...