6 documents found, page 1 of 1
Praziquantel-loaded solid lipid nanoparticles: Production, physicochemical char...
Andrade, Luciana Nalone; Marques, Conrado; Barbosa, Thallysson; Santos, Rafael; Chaud, Marco Vinícius; Ferreira da Silva, ClassiusPraziquantel (PZQ) is an anthelmintic drug, being the first choice for the treatment of schistosomiasis. Its high hydrophobic character and its low water solubility are the main limitations to the development of liquid formulations for the oral administration of the drug. The aim of this work was to develop Solid Lipid Nanoparticles (SLN) for the loading of PZQ for the treatment of S. mansoni infections. PZQ-SL...
A novel approach in mucoadhesive drug delivery system to improve zidovudine int...
Pedreiro, Liliane Neves [UNESP]; Cury, Beatriz Stringhetti Ferreira [UNESP]; Chaud, Marco Vinícius; Gremião, Maria Palmira Daflon [UNESP]Made available in DSpace on 2018-12-11T17:31:34Z (GMT). No. of bitstreams: 0 Previous issue date: 2016-10-01. Added 1 bitstream(s) on 2021-07-15T15:22:23Z : No. of bitstreams: 1 S1984-82502016000400715.pdf: 865574 bytes, checksum: 136455b7fdf4758825e3e2c400794485 (MD5); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Zidovudine ...
Supercritical fluid and pharmaceutical applications. Part I: Process classifica...
Yoshida, V. M. H.; Balcão, V. M.; Vila, Marta Maria Duarte Carvalho; Júnior, José Martins Oliveira; Aranha, Norberto; Gremião, Maria Palmira DaflonThe supercritical fluid technology has been target of many pharmaceuticals investigations in particles production for almost 35 years. This is due to the great advantages it offers over others technologies currently used for the same purpose. A brief history is presented, as well the classification of supercritical technology based on the role that the supercritical fluid (carbon dioxide) performs in the process.
A novel approach in mucoadhesive drug delivery system to improve zidovudine int...
Pedreiro, Liliane Neves; Cury, Beatriz Stringhetti Ferreira; Chaud, Marco Vinícius; Gremião, Maria Palmira DaflonZidovudine (AZT) mucoadhesive solid dispersions (SD) were prepared using a sodium starch glycolate (SSG) and hypromellose phthalate (HPMCP) mixtures as carrier to enhance the intestinal permeability and bioavailability of zidovudine. SDs were prepared using the co-precipitation method followed by solvent evaporation and characterized according to their physicochemical properties such as particle size, crystalli...
A novel dosage form for buccal administration of bupropion
Almeida, Nilsa Maria Galvão; Lima, Renata; Alves, Thaís Francine Ribeiro; Rebelo, Márcia de Araújo; Severino, Patrícia; Chaud, Marco ViníciusA bupropiona é um antidepressivo utilizado no tratamento do tabagismo. O objetivo deste trabalho foi a preparação de filmes hidrogelatinosos de liberação controlada para administração bucal de bupropiona. Os filmes foram preparados utilizando carboximetilcelulose sódica ultrapurificada, hidroxipropilmetilcelulose K4M e quitosana de média viscosidade. As características físico-químicas dos filmes foram avaliadas...
Força de compressão e umidade no perfil de dissolução da hidroclorotiazida
De Lima, Andréa Cristina [UNESP]; Michelin, Daniele Carvalho [UNESP]; Santos, Manoel Roberta Da Cruz; Paganelli, Maria Ondina; Ignácio, Rosa FernandaSubmitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-27T11:21:48Z No. of bitstreams: 0; Made available in DSpace on 2014-05-27T11:21:48Z (GMT). No. of bitstreams: 0 Previous issue date: 2006-01-01; The aim of this work was to evaluate the influence of compression force and humidity in the dissolution profile of tablets formulation. As hidroclorotyiazide presents real problems of ...